Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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P287387-5mg | 5mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $98.90 | |
P287387-10mg | 10mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $157.90 | |
P287387-25mg | 25mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $345.90 | |
P287387-50mg | 50mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $573.90 | |
P287387-100mg | 100mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $890.90 | |
P287387-250mg | 250mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $2,004.90 |
JARID1 (Jumonji AT-Rich Interactive Domain 1) inhibitor
Synonyms | Z275617084 | 2-(4-methylphenyl)-2,3-dihydro-1,2-benzothiazol-3-one | A14366 | ChemDiv3_007090 | BRD-K31634845-001-01-1 | 1,2-Benzisothiazol-3(2H)-one, 2-(4-methylphenyl)- | 2-(p-Tolyl)benzo[d]isothiazol-3(2H)-one | CAA51430 | CS-0021365 | 2-(4-methylpheny |
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Specifications & Purity | Moligand™, ≥98%(HPLC) |
Biochemical and Physiological Mechanisms | JARID1 (Jumonji AT-Rich Interactive Domain 1) inhibitor (IC50values are 3, 4.9 and 6μM for JARID1B, 1A and 1C, respectively). Selective for JARID1 over UTX and JMJD3. Increases levels of methylated H3K4 in JARIDB1-transfected HeLa cells and MCF7 cells. I |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of lysine demethylase 5A;Inhibitor of lysine demethylase 5B;Inhibitor of lysine demethylase 5C |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 2-(4-methylphenyl)-1,2-benzothiazol-3-one |
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INCHI | InChI=1S/C14H11NOS/c1-10-6-8-11(9-7-10)15-14(16)12-4-2-3-5-13(12)17-15/h2-9H,1H3 |
InChi Key | KRXMYBAZKJBJAB-UHFFFAOYSA-N |
Canonical SMILES | CC1=CC=C(C=C1)N2C(=O)C3=CC=CC=C3S2 |
Isomeric SMILES | CC1=CC=C(C=C1)N2C(=O)C3=CC=CC=C3S2 |
WGK Germany | 3 |
PubChem CID | 935415 |
Molecular Weight | 241.31 |
PubChem CID | 935415 |
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CAS Registry No. | 2514-30-9 |
ChEMBL Ligand | CHEMBL1336959 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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F2205497 | Certificate of Analysis | Mar 22, 2022 | P287387 |
F2205498 | Certificate of Analysis | Mar 22, 2022 | P287387 |
F2205500 | Certificate of Analysis | Mar 22, 2022 | P287387 |
F2205501 | Certificate of Analysis | Mar 22, 2022 | P287387 |
F2205503 | Certificate of Analysis | Mar 22, 2022 | P287387 |
F2205505 | Certificate of Analysis | Mar 22, 2022 | P287387 |
Solubility | Solvent:DMSO, Max Conc. mg/mL: 24.13, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 4.83, Max Conc. mM: 20 |
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Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
RIDADR | NONHforallmodesoftransport |
1. Sayegh J, Cao J, Zou MR, Morales A, Blair LP, Norcia M, Hoyer D, Tackett AJ, Merkel JS, Yan Q. (2013) Identification of small molecule inhibitors of Jumonji AT-rich interactive domain 1B (JARID1B) histone demethylase by a sensitive high throughput screen.. J Biol Chem, 288 (13): (9408-17). [PMID:23408432] [10.1021/op500134e] |