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PBTZ169 - 98%, high purity , FAD-dependent decaprenylphosphoryl-beta-D-ribofuranose 2-oxidase inhibitor, CAS No.1377239-83-2, FAD-dependent decaprenylphosphoryl-beta-D-ribofuranose 2-oxidase inhibitor

≥98%

CAS#: 1377239-83-2
Formula: C₂₀H₂₃F₃N₄O₃S
Molecular Weight: 456.48
PubChem CID: 57331386
PubChem SID: 488201816

Item Number

P413514

Grouped product items
SKU	Size	Availability	Price
P413514-5mg	5mg	In stock	$141.90
P413514-10mg	10mg	In stock	$236.90
P413514-25mg	25mg	In stock	$533.90
P413514-50mg	50mg	In stock	$771.90
P413514-100mg	100mg	In stock	$1,127.90
P413514-250mg	250mg	In stock	$2,538.90

Antibiotics Inhibitors

Basic Description

Synonyms	PBTZ169 \| Macozinone \| 1377239-83-2 \| PBTZ-169 \| Macozinone [INN] \| 2-(4-(cyclohexylmethyl)piperazin-1-yl)-8-nitro-6-(trifluoromethyl)-4H-benzo[e][1,3]thiazin-4-one \| A3M1353L40 \| 2-(4-(Cyclohexylmethyl)piperazin-1-yl)-8-nitro-6-trifluoromethyl-4H-1,3-benzothiazin-4-on
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	PBTZ169 (macozinone), an antibiotic with antimycobacterial activity, is an irreversible inhibitor of DprE1.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Action Type	INHIBITOR
Mechanism of action	FAD-dependent decaprenylphosphoryl-beta-D-ribofuranose 2-oxidase inhibitor
Product Description	Information PBTZ169 PBTZ169 (macozinone), an antibiotic with antimycobacterial activity, is an irreversible inhibitor of DprE1 .

Associated Targets(Human)

KCNH2 Tclin HERG (29587 Activities)

Discover Target: KCNH2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)

Discover Target: CYP2C9

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)

Discover Target: CYP2C19

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)

Discover Target: CYP3A4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HEK293 (82097 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HepG2 (196354 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Pseudomonas aeruginosa (123386 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Klebsiella pneumoniae (43867 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Staphylococcus aureus (210822 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Acinetobacter baumannii (41033 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Escherichia coli (133304 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mycobacterium tuberculosis (203094 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Cryptococcus neoformans (21258 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Candida albicans (78123 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mus musculus (284745 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Vero (26788 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

dprE1 FAD-dependent decaprenylphosphoryl-beta-D-ribofuranose 2-oxidase (13 Activities)

Discover Target: dprE1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

Pubchem Sid	488201816
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488201816
IUPAC Name	2-[4-(cyclohexylmethyl)piperazin-1-yl]-8-nitro-6-(trifluoromethyl)-1,3-benzothiazin-4-one
INCHI	InChI=1S/C20H23F3N4O3S/c21-20(22,23)14-10-15-17(16(11-14)27(29)30)31-19(24-18(15)28)26-8-6-25(7-9-26)12-13-4-2-1-3-5-13/h10-11,13H,1-9,12H2
InChi Key	BJDZBXGJNBMCAV-UHFFFAOYSA-N
Canonical SMILES	C1CCC(CC1)CN2CCN(CC2)C3=NC(=O)C4=C(S3)C(=CC(=C4)C(F)(F)F)[N+](=O)[O-]
Isomeric SMILES	C1CCC(CC1)CN2CCN(CC2)C3=NC(=O)C4=C(S3)C(=CC(=C4)C(F)(F)F)[N+](=O)[O-]
PubChem CID	57331386
Molecular Weight	456.48

Certificates

Certificate of Analysis(COA)

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12 results found

Lot Number	Certificate Type	Date	Item
C2316321	Certificate of Analysis	Dec 05, 2022	P413514
C2316327	Certificate of Analysis	Dec 05, 2022	P413514
C2316331	Certificate of Analysis	Dec 05, 2022	P413514
C2316337	Certificate of Analysis	Dec 05, 2022	P413514
C2316341	Certificate of Analysis	Dec 05, 2022	P413514
C2316356	Certificate of Analysis	Dec 05, 2022	P413514
C2316360	Certificate of Analysis	Dec 05, 2022	P413514
C2316361	Certificate of Analysis	Dec 05, 2022	P413514
C2316362	Certificate of Analysis	Dec 05, 2022	P413514
C2316365	Certificate of Analysis	Dec 05, 2022	P413514
C2316366	Certificate of Analysis	Dec 05, 2022	P413514
C2316367	Certificate of Analysis	Dec 05, 2022	P413514

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H302:Harmful if swallowed
Precautionary Statements	P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help.

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PBTZ169 - 98%, high purity , FAD-dependent decaprenylphosphoryl-beta-D-ribofuranose 2-oxidase inhibitor, CAS No.1377239-83-2, FAD-dependent decaprenylphosphoryl-beta-D-ribofuranose 2-oxidase inhibitor

Basic Description

Product Properties

Associated Targets(Human)

Associated Targets(non-human)

Names and Identifiers

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Safety and Hazards(GHS)

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