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PCI 29732 - ≥99%(HPLC), high purity , CAS No.330786-25-9

≥99%(HPLC)

CAS#: 330786-25-9
Formula: C₂₂H₂₁N₅O
Molecular Weight: 371.44
PubChem CID: 22347110

Item Number

P287191

Grouped product items
SKU	Size	Availability	Price
P287191-5mg	5mg	In stock	$98.90
P287191-10mg	10mg	In stock	$157.90
P287191-25mg	25mg	In stock	$355.90
P287191-50mg	50mg	In stock	$553.90
P287191-100mg	100mg	In stock	$969.90

Potent BTK inhibitor

Basic Description

Synonyms	A924331 \| AC-32586 \| AS-56056 \| C22H21N5O \| 4-amino-1-cyclopentyl-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidine \| HY-18010 \| PCI 29732 \| s6725 \| BCP30138 \| GMJUPMONHWAZCP-UHFFFAOYSA-N \| 1-Cyclopentyl-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-am
Specifications & Purity	≥99%(HPLC)
Biochemical and Physiological Mechanisms	Potent BTK inhibitor (IC50= 0.3 nM). Blocks B cell antigen receptor (BCR)-mediated gene expression in CD20+B cells.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads

Associated Targets(Human)

BTK Tclin Tyrosine-protein kinase BTK (2 Activities)

Discover Target: BTK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HEK293 (82097 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

BTK Tclin Tyrosine-protein kinase BTK (8973 Activities)

Discover Target: BTK

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	1-cyclopentyl-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-4-amine
INCHI	InChI=1S/C22H21N5O/c23-21-19-20(26-27(16-6-4-5-7-16)22(19)25-14-24-21)15-10-12-18(13-11-15)28-17-8-2-1-3-9-17/h1-3,8-14,16H,4-7H2,(H2,23,24,25)
InChi Key	GMJUPMONHWAZCP-UHFFFAOYSA-N
Canonical SMILES	C1CCC(C1)N2C3=NC=NC(=C3C(=N2)C4=CC=C(C=C4)OC5=CC=CC=C5)N
Isomeric SMILES	C1CCC(C1)N2C3=NC=NC(=C3C(=N2)C4=CC=C(C=C4)OC5=CC=CC=C5)N
PubChem CID	22347110
Molecular Weight	371.44

Certificates

Certificate of Analysis(COA)

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5 results found

Lot Number	Certificate Type	Date	Item
B2323067	Certificate of Analysis	Dec 12, 2022	P287191
B2323070	Certificate of Analysis	Dec 12, 2022	P287191
B2323074	Certificate of Analysis	Dec 12, 2022	P287191
B2323081	Certificate of Analysis	Dec 12, 2022	P287191
B2323082	Certificate of Analysis	Dec 12, 2022	P287191

Solubility

Solvent:DMSO, Max Conc. mg/mL: 37.14, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 18.57, Max Conc. mM: 50

Sensitivity

heat sensitive

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