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PCO 400 , CAS No.121055-10-5
an analog of comakalim that acts as a selective and potent ATP-sensitive K+ channel opener
Basic Description Synonyms NCGC00163140-01 | (3S,4R)-3-hydroxy-2,2-dimethyl-4-[(3-oxocyclopent-1-en-1-yl)oxy]-3,4-dihydro-2H-1-benzopyran-6-carbonitrile | KBioGR_000149 | GLYPHOSATE [IARC] | KBio2_000149 | 3-Hydroxy-2,2-dimethyl-4-[(3-oxocyclopent-1-en-1-yl)oxy]-3,4-dihydro-2H-1-be Storage Temp Room temperature Shipped In Normal Product Description PCO 400 is an analog of comakalim and a selective and potent ATP-sensitive K|+|channel opener. It has been shown to evoke relaxation of isolated airway smooth muscle in a dose-dependent manner. Upon intravenous injection, transient inhibition of histamine-induced bronchospasm was effected. Inhaled as a dry powder, it can suppress the development of allergic airway hyperreactivity to histamine.
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name (3S,4R)-3-hydroxy-2,2-dimethyl-4-(3-oxocyclopenten-1-yl)oxy-3,4-dihydrochromene-6-carbonitrile INCHI InChI=1S/C17H17NO4/c1-17(2)16(20)15(21-12-5-4-11(19)8-12)13-7-10(9-18)3-6-14(13)22-17/h3,6-8,15-16,20H,4-5H2,1-2H3/t15-,16+/m1/s1 InChi Key WJBHHTPFTVKZCV-CVEARBPZSA-N Canonical SMILES CC1(C(C(C2=C(O1)C=CC(=C2)C#N)OC3=CC(=O)CC3)O)C Isomeric SMILES CC1([C@H]([C@@H](C2=C(O1)C=CC(=C2)C#N)OC3=CC(=O)CC3)O)C PubChem CID 129348 Molecular Weight 299.32
Chemical and Physical Properties Solubility Soluble in ethanol (30 mg/ml), and DMSO (>200 mg/ml). Refractive Index n20D1.61 (Predicted) Boil Point(°C) 496.7° C at 760 mmHg (Predicted) Melt Point(°C) 154-156° C
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