JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.

྾

Home
Oncology
Tumor Biomarkers
Tumor antigens
PD-1/PD-L1 inhibitor 1 - ≥98%, high purity , CAS No.1675201-83-8

Skip to the end of the images gallery

Skip to the beginning of the images gallery

PD-1/PD-L1 inhibitor 1 - ≥98%, high purity , CAS No.1675201-83-8

≥98%

CAS#: 1675201-83-8
Formula: C₂₉H₃₃NO₅
Molecular Weight: 475.6
PubChem CID: 91663303

Item Number

P276510

Grouped product items
SKU	Size	Availability	Price
P276510-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$34.90
P276510-5mg	5mg	In stock	$141.90
P276510-10mg	10mg	In stock	$224.90
P276510-25mg	25mg	In stock	$450.90
P276510-50mg	50mg	In stock	$652.90
P276510-100mg	100mg	In stock	$1,044.90
P276510-250mg	250mg	In stock	$2,351.90

Small molecule inhibitor of PD-1/PD-L1 interaction

Basic Description

Synonyms	(2S)-1-[[2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl]methyl]piperidine-2-carboxylicacid;(S)-1-(2,6-dimethoxy-4-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)benzyl)piperidine-2-carboxylic acid;PD1-PDL1-IN1;BMS-1
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	In the cell-free HTRF test, PD-1/PD-L1 inhibitor 1 blocked the PD-1/PD-L1 interaction with an IC50 of 6 nM.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	Shipped at 4°C. Store at -20°C.

Associated Targets(Human)

CD274 Tclin Programmed cell death 1 ligand 1 (1 Activities)

Discover Target: CD274

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Jurkat (10389 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CD274 Tclin Programmed cell death 1 ligand 1 (299 Activities)

Discover Target: CD274

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PDCD1 Tclin Programmed cell death protein 1/Programmed cell death 1 ligand 1 (1367 Activities)

Discover Target: PDCD1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	(2S)-1-[[2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl]methyl]piperidine-2-carboxylic acid
INCHI	InChI=1S/C29H33NO5/c1-20-22(12-9-13-24(20)21-10-5-4-6-11-21)19-35-23-16-27(33-2)25(28(17-23)34-3)18-30-15-8-7-14-26(30)29(31)32/h4-6,9-13,16-17,26H,7-8,14-15,18-19H2,1-3H3,(H,31,32)/t26-/m0/s1
InChi Key	ZBOYJODMIAUJHH-SANMLTNESA-N
Canonical SMILES	CC1=C(C=CC=C1C2=CC=CC=C2)COC3=CC(=C(C(=C3)OC)CN4CCCCC4C(=O)O)OC
Isomeric SMILES	CC1=C(C=CC=C1C2=CC=CC=C2)COC3=CC(=C(C(=C3)OC)CN4CCCC[C@H]4C(=O)O)OC
PubChem CID	91663303
Molecular Weight	475.6

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

8 results found

Lot Number	Certificate Type	Date	Item
A2429378	Certificate of Analysis	Feb 18, 2024	P276510
K2216702	Certificate of Analysis	Sep 13, 2023	P276510
K2216749	Certificate of Analysis	Sep 13, 2023	P276510
K2216772	Certificate of Analysis	Sep 13, 2023	P276510
K2216833	Certificate of Analysis	Sep 13, 2023	P276510
K2216834	Certificate of Analysis	Sep 13, 2023	P276510
K2216835	Certificate of Analysis	Sep 13, 2023	P276510
K2216773	Certificate of Analysis	Oct 17, 2022	P276510

Chemical and Physical Properties

Solubility	200 mM in DMSO 200 mM in water 200 mM in ethanol；insoluble in H2O; insoluble in EtOH; ≥5.98 mg/mL in DMSO with gentle warming and ultrasonic

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

Alternative Products

FAQs and Articles

FAQ

PD-1/PD-L1 Signaling Pathway

Categories: Technical articles

Tags:

PD-1 PD-L1 Cancer immunosuppression

References

1. Xia W et al.. (2020) PD-L1 Inhibitor Regulates the miR-33a-5p/PTEN Signaling Pathway and Can Be Targeted to Sensitize Glioblastomas to Radiation.. Front Oncol, 10 (821). [PMID:32537433]
2. Zhang G. (2022) Regulatory T-cells-related signature for identifying a prognostic subtype of hepatocellular carcinoma with an exhausted tumor microenvironment.. Front Immunol, 13 (975762). [PMID:36189226]
3. Yun T et al.. (2020) Significance of Detection of the HER2 Gene and PD-1/PD-L1 in Gastric Cancer.. J Oncol, 2020 (8678945). [PMID:33123197]

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.