PD-1/PD-L1 inhibitor 1 - ≥98%, high purity , CAS No.1675201-83-8

Item Number

P276510

Grouped product items
SKU	Size	Availability	Price
P276510-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$34.90
P276510-5mg	5mg	In stock	$141.90
P276510-10mg	10mg	In stock	$224.90
P276510-25mg	25mg	In stock	$450.90
P276510-50mg	50mg	In stock	$652.90
P276510-100mg	100mg	In stock	$1,044.90
P276510-250mg	250mg	In stock	$2,351.90

Small molecule inhibitor of PD-1/PD-L1 interaction

Basic Description

Synonyms	(2S)-1-[[2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl]methyl]piperidine-2-carboxylicacid;(S)-1-(2,6-dimethoxy-4-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)benzyl)piperidine-2-carboxylic acid;PD1-PDL1-IN1;BMS-1
Specifications & Purity	≥98%
Storage Temp	Store at -20°C
Shipped In	Dry ice
Product Description	Shipped at 4°C. Store at -20°C.

Names and Identifiers

IUPAC Name	(2S)-1-[[2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl]methyl]piperidine-2-carboxylic acid
INCHI	InChI=1S/C29H33NO5/c1-20-22(12-9-13-24(20)21-10-5-4-6-11-21)19-35-23-16-27(33-2)25(28(17-23)34-3)18-30-15-8-7-14-26(30)29(31)32/h4-6,9-13,16-17,26H,7-8,14-15,18-19H2,1-3H3,(H,31,32)/t26-/m0/s1
InChi Key	ZBOYJODMIAUJHH-SANMLTNESA-N
Canonical SMILES	CC1=C(C=CC=C1C2=CC=CC=C2)COC3=CC(=C(C(=C3)OC)CN4CCCCC4C(=O)O)OC
Isomeric SMILES	CC1=C(C=CC=C1C2=CC=CC=C2)COC3=CC(=C(C(=C3)OC)CN4CCCC[C@H]4C(=O)O)OC
PubChem CID	91663303
Molecular Weight	475.6

Certificates

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8 results found

Lot Number	Certificate Type	Date	Item
A2429378	Certificate of Analysis	Feb 18, 2024	P276510
K2216702	Certificate of Analysis	Sep 13, 2023	P276510
K2216749	Certificate of Analysis	Sep 13, 2023	P276510
K2216772	Certificate of Analysis	Sep 13, 2023	P276510
K2216833	Certificate of Analysis	Sep 13, 2023	P276510
K2216834	Certificate of Analysis	Sep 13, 2023	P276510
K2216835	Certificate of Analysis	Sep 13, 2023	P276510
K2216773	Certificate of Analysis	Oct 17, 2022	P276510

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

References

1. Xia W et al.. (2020) PD-L1 Inhibitor Regulates the miR-33a-5p/PTEN Signaling Pathway and Can Be Targeted to Sensitize Glioblastomas to Radiation.. Front Oncol, 10 (821). [PMID:32537433]
2. Zhang G. (2022) Regulatory T-cells-related signature for identifying a prognostic subtype of hepatocellular carcinoma with an exhausted tumor microenvironment.. Front Immunol, 13 (975762). [PMID:36189226]
3. Yun T et al.. (2020) Significance of Detection of the HER2 Gene and PD-1/PD-L1 in Gastric Cancer.. J Oncol, 2020 (8678945). [PMID:33123197]

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Basic Description