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PD-1/PD-L1 inhibitor 1 - ≥98%, high purity , CAS No.1675201-83-8

  • ≥98%
Item Number
P276510
Grouped product items
SKUSizeAvailabilityPrice Qty
P276510-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$34.90
P276510-5mg
5mg
In stock
$141.90
P276510-10mg
10mg
In stock
$224.90
P276510-25mg
25mg
In stock
$450.90
P276510-50mg
50mg
In stock
$652.90
P276510-100mg
100mg
In stock
$1,044.90
P276510-250mg
250mg
In stock
$2,351.90
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Small molecule inhibitor of PD-1/PD-L1 interaction

Basic Description

Specifications & Purity≥98%
Biochemical and Physiological MechanismsIn the cell-free HTRF test, PD-1/PD-L1 inhibitor 1 blocked the PD-1/PD-L1 interaction with an IC50 of 6 nM.
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
Product Description

Shipped at 4°C. Store at -20°C.

Associated Targets(Human)

CD274 Tclin Programmed cell death 1 ligand 1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
Jurkat (10389 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CD274 Tclin Programmed cell death 1 ligand 1 (299 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name (2S)-1-[[2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl]methyl]piperidine-2-carboxylic acid
INCHI InChI=1S/C29H33NO5/c1-20-22(12-9-13-24(20)21-10-5-4-6-11-21)19-35-23-16-27(33-2)25(28(17-23)34-3)18-30-15-8-7-14-26(30)29(31)32/h4-6,9-13,16-17,26H,7-8,14-15,18-19H2,1-3H3,(H,31,32)/t26-/m0/s1
InChi Key ZBOYJODMIAUJHH-SANMLTNESA-N
Canonical SMILES CC1=C(C=CC=C1C2=CC=CC=C2)COC3=CC(=C(C(=C3)OC)CN4CCCCC4C(=O)O)OC
Isomeric SMILES CC1=C(C=CC=C1C2=CC=CC=C2)COC3=CC(=C(C(=C3)OC)CN4CCCC[C@H]4C(=O)O)OC
PubChem CID 91663303
Molecular Weight 475.6

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

9 results found

Lot NumberCertificate TypeDateItem
A2431239Certificate of AnalysisNov 05, 2024 P276510
A2429378Certificate of AnalysisFeb 18, 2024 P276510
K2216702Certificate of AnalysisSep 13, 2023 P276510
K2216749Certificate of AnalysisSep 13, 2023 P276510
K2216772Certificate of AnalysisSep 13, 2023 P276510
K2216833Certificate of AnalysisSep 13, 2023 P276510
K2216834Certificate of AnalysisSep 13, 2023 P276510
K2216835Certificate of AnalysisSep 13, 2023 P276510
K2216773Certificate of AnalysisOct 17, 2022 P276510

Chemical and Physical Properties

Solubility200 mM in DMSO 200 mM in water 200 mM in ethanol；insoluble in H2O; insoluble in EtOH; ≥5.98 mg/mL in DMSO with gentle warming and ultrasonic

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

H302:Harmful if swallowed

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

Related Documents

 SDS

 Specification Sheet

Alternative Products

  1. PD-1/PD-L1 inhibitor 1 - 10mM in DMSO, used for , CAS No. 1675201-83-8, by Aladdin Scientific
    PD-1/PD-L1 inhibitor 1
    • 10mM in DMSO

    Starting at $75.90

FAQs and Articles

FAQ
PD-1/PD-L1 Signaling Pathway
Categories: Technical articles
Tags:
PD-1 PD-L1 Cancer immunosuppression

References

1. Xia W et al..  (2020)  PD-L1 Inhibitor Regulates the miR-33a-5p/PTEN Signaling Pathway and Can Be Targeted to Sensitize Glioblastomas to Radiation..  Front Oncol,  10  (821).  [PMID:32537433]
2. Zhang G.  (2022)  Regulatory T-cells-related signature for identifying a prognostic subtype of hepatocellular carcinoma with an exhausted tumor microenvironment..  Front Immunol,  13  (975762).  [PMID:36189226]
3. Yun T et al..  (2020)  Significance of Detection of the HER2 Gene and PD-1/PD-L1 in Gastric Cancer..  J Oncol,  2020  (8678945).  [PMID:33123197]

Solution Calculators

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