PD-1/PD-L1 inhibitor 1 - 10mM in DMSO, high purity , CAS No.1675201-83-8

Item Number

P422075

Grouped product items
SKU	Size	Availability	Price	Qty
P422075-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$75.90

Small molecule inhibitor of PD-1/PD-L1 interaction

Basic Description

Synonyms	(2S)-1-[[2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl]methyl]piperidine-2-carboxylicacid；(S)-1-(2,6-dimethoxy-4-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)benzyl)piperidine-2-carboxylic acid；PD1-PDL1-IN1
Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	In the cell-free HTRF test, PD-1/PD-L1 inhibitor 1 blocked the PD-1/PD-L1 interaction with an IC50 of 6 nM.
Storage Temp	Store at -80°C
Shipped In	Dry ice

Names and Identifiers

IUPAC Name	(2S)-1-[[2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl]methyl]piperidine-2-carboxylic acid
INCHI	InChI=1S/C29H33NO5/c1-20-22(12-9-13-24(20)21-10-5-4-6-11-21)19-35-23-16-27(33-2)25(28(17-23)34-3)18-30-15-8-7-14-26(30)29(31)32/h4-6,9-13,16-17,26H,7-8,14-15,18-19H2,1-3H3,(H,31,32)/t26-/m0/s1
InChi Key	ZBOYJODMIAUJHH-SANMLTNESA-N
Canonical SMILES	CC1=C(C=CC=C1C2=CC=CC=C2)COC3=CC(=C(C(=C3)OC)CN4CCCCC4C(=O)O)OC
Isomeric SMILES	CC1=C(C=CC=C1C2=CC=CC=C2)COC3=CC(=C(C(=C3)OC)CN4CCCC[C@H]4C(=O)O)OC
PubChem CID	91663303
Molecular Weight	475.6

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

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Basic Description