Potent, selective, non-peptide angiotensin AT 2 receptor antagonist
Basic Description
Synonyms
S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid di(trifluoroacetate) salt hydrate
Specifications & Purity
≥98%
Biochemical and Physiological Mechanisms
Potent, selective, non-peptide angiotensin AT 2 receptor antagonist (IC 50 values are 34 and 210 nM for rat adrenal and brain tissue respectively). Reduces angiotensin II-induced oxidative stress. Orally active.
Storage Temp
Store at -20°C,Desiccated
Shipped In
Ice chest + Ice pads
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Associated Targets(Human)
AGTR2TchemType-2 angiotensin II receptor (4 Activities)
1.Hu B et al.. (2018) Angiotensin II facilitates GABAergic neurotransmission at postsynaptic sites in rat amygdala neurons.. Neuropharmacology, 133 (334-344). [PMID:29447844]
Solution Calculators
Molarity Calculator
Determine the necessary mass, volume, or concentration for preparing a solution.
Dilution Calculator
Determine the dilution needed to prepare a stock solution.