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PD 135158 , CAS No.130325-35-8, Antagonist of CCK 1 receptor;Antagonist of CCK 2 receptor

CAS#: 130325-35-8
Formula: C₃₅H₄₄N₄O₆
Molecular Weight: 616.76
PubChem CID: 146156889

Item Number

P332332

Grouped product items
SKU	Size	Availability	Price	Qty
P332332-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$223.90
P332332-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$942.90

a selective CCK-BR antagonist used for research purposes

View related series

CCK1 receptor Antagonist CCK2 receptor Antagonist Cholecystokinin Receptor GPCR/G Protein Neuronal Signaling

Basic Description

Specifications & Purity	Moligand™
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of CCK 1 receptor;Antagonist of CCK 2 receptor
Product Description	PD 135158 is a specific and effective CCK-BR antagonist (cholecystokinin type B). CCK is a neuroendocrine peptide described to play an important role in cell growth, cell proliferation, and other biological functions. PD 135158 has been reported to show limited affinity for substance P, benzodiazepine, GABA\|A\|, neurotensin, bradykinin, and 5-HT3 binding sites.

Associated Targets(Human)

CCKAR Tclin Cholecystokinin receptor type A (1 Activities)

Discover Target: CCKAR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CCKBR Tclin Gastrin/cholecystokinin type B receptor (1 Activities)

Discover Target: CCKBR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	4-[[2-[[(2R)-3-(1H-indol-3-yl)-2-methyl-2-[[(1S)-1,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl]oxycarbonylamino]propanoyl]amino]-1-phenylethyl]amino]-4-oxobutanoic acid
INCHI	InChI=1S/C35H44N4O6/c1-33(2)24-16-17-34(33,3)28(18-24)45-32(44)39-35(4,19-23-20-36-26-13-9-8-12-25(23)26)31(43)37-21-27(22-10-6-5-7-11-22)38-29(40)14-15-30(41)42/h5-13,20,24,27-28,36H,14-19,21H2,1-4H3,(H,37,43)(H,38,40)(H,39,44)(H,41,42)/t24?,27?,28?,34-,35-/m1/s1
InChi Key	NNTPEWZUKRSTMM-AGYKWCBDSA-N
Canonical SMILES	CC1(C2CCC1(C(C2)OC(=O)NC(C)(CC3=CNC4=CC=CC=C43)C(=O)NCC(C5=CC=CC=C5)NC(=O)CCC(=O)O)C)C
RTECS	LZ4366600
PubChem CID	146156889
Molecular Weight	616.76

PubChem CID

BindingDB Ligand

CAS Registry No.

GPCRdb Ligand

Solubility

Soluble in DMSO (100 mM).

Refractive Index

n20D1.63 (Predicted)

Specific Rotation[α]

α20/D -23.6°, c = 1 in acetone

Boil Point(°C)

~908.8° C at 760 mmHg (Predicted)

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PD 135158 , CAS No.130325-35-8, Antagonist of CCK 1 receptor;Antagonist of CCK 2 receptor

Basic Description

Product Properties

Associated Targets(Human)

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

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