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PD 146176 - ≥98%(HPLC), high purity , CAS No.4079-26-9, Inhibitor of 15-LOX-1
Selective 15-lipoxygenase inhibitor
Basic Description
| Specifications & Purity | Moligand™, ≥98%(HPLC) |
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| Biochemical and Physiological Mechanisms | PD 146176 blocks neuroprotectin D1 (NPD1) and eicosanoid synthesis by inhibiting the 5-lipoxygenase-1 (15-LOX-1) enzyme.
15-Lipoxygenase inhibitor |
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| Storage Temp | Store at -20°C |
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| Shipped In | Ice chest + Ice pads |
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| Grade | Moligand™ |
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| Action Type | INHIBITOR |
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| Mechanism of action | Inhibitor of 15-LOX-1 |
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| Product Description | PD 146176 has been used to study its influence on ex vivo leukotriene B4 (LTB4) and lipoxin A4 (LXA4) secretion in adipose tissue.
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Associated Targets(Human)
Associated Targets(non-human)
Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Names and Identifiers
| IUPAC Name | 6,11-dihydrothiochromeno[4,3-b]indole |
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| INCHI | InChI=1S/C15H11NS/c1-3-7-13-10(5-1)12-9-17-14-8-4-2-6-11(14)15(12)16-13/h1-8,16H,9H2 |
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| InChi Key | ZGOOPZVQMLHPFM-UHFFFAOYSA-N |
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| Canonical SMILES | C1C2=C(C3=CC=CC=C3S1)NC4=CC=CC=C24 |
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| Isomeric SMILES | C1C2=C(C3=CC=CC=C3S1)NC4=CC=CC=C24 |
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| Alternate CAS | 4079-26-9 |
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| PubChem CID | 297589 |
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| NSC Number | 168807 |
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| MeSH Entry Terms | 6,11-dihydro-5-thia-11-aza-benzo(a)-fluorene;PD 146176;PD-146176 |
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| Molecular Weight | 237.32 |
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Chemical and Physical Properties
| Solubility | Solvent:DMSO, Max Conc. mg/mL: 23.73, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 11.87, Max Conc. mM: 50 |
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References
| 1. Sendobry SM, Cornicelli JA, Welch K, Bocan T, Tait B, Trivedi BK, Colbry N, Dyer RD, Feinmark SJ, Daugherty A. (1997) Attenuation of diet-induced atherosclerosis in rabbits with a highly selective 15-lipoxygenase inhibitor lacking significant antioxidant properties.. Br J Pharmacol, 120 (7): (1199-206). [PMID:9105693] |
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