PD 151746 - 95%, high purity , CAS No.179461-52-0

  • ≥95%
Item Number
P276048
Grouped product items
SKUSizeAvailabilityPrice Qty
P276048-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$55.90
P276048-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$178.90
P276048-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$284.90
P276048-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$455.90

Cell permeable, selective, non-peptidic calpain inhibitor

Basic Description

Specifications & Purity≥95%
Biochemical and Physiological MechanismsCell permeable, selective, non-peptidic calpain inhibitor (K i values are 0.3 and 5 μM for calpain 1 and calpain 2, respectively). Stimulates phagocyte function via hFPR/hFPRL1 activation. Interacts with the Ca 2+ calpain sites.
Storage TempProtected from light,Store at -20°C,Desiccated
Shipped InIce chest + Ice pads
NoteUnstable; make up solutions fresh and use immediately. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.

Associated Targets(Human)

CAPN1 Tchem Calpain-1 catalytic subunit (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CAPN2 Tchem Calpain 2 (185 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

CAPN1 Calpain 1 (219 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name (Z)-3-(5-fluoro-1H-indol-3-yl)-2-sulfanylprop-2-enoic acid
INCHI InChI=1S/C11H8FNO2S/c12-7-1-2-9-8(4-7)6(5-13-9)3-10(16)11(14)15/h1-5,13,16H,(H,14,15)/b10-3-
InChi Key HWMQHECFXSVZGN-KMKOMSMNSA-N
Canonical SMILES C1=CC2=C(C=C1F)C(=CN2)C=C(C(=O)O)S
Isomeric SMILES C1=CC2=C(C=C1F)C(=CN2)/C=C(/C(=O)O)\S
WGK Germany 3
PubChem CID 5353866
Molecular Weight 237.25

Certificates

Certificate of Analysis(COA)

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8 results found

Lot NumberCertificate TypeDateItem
G2402290Certificate of AnalysisMar 06, 2024 P276048
G2408173Certificate of AnalysisMar 06, 2024 P276048
G2408174Certificate of AnalysisMar 06, 2024 P276048
G2408225Certificate of AnalysisMar 06, 2024 P276048
G2408230Certificate of AnalysisMar 06, 2024 P276048
G2408231Certificate of AnalysisMar 06, 2024 P276048
G2408232Certificate of AnalysisMar 06, 2024 P276048
G2408234Certificate of AnalysisMar 06, 2024 P276048

Chemical and Physical Properties

SolubilitySoluble in DMSO to 100 mM
Sensitivityair and light sensitive

Safety and Hazards(GHS)

WGK Germany 3
RIDADR NONHforallmodesoftransport

Related Documents

Solution Calculators