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PD 151746 - 10mM in DMSO, high purity , CAS No.179461-52-0

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PD 151746 - 10mM in DMSO, high purity , CAS No.179461-52-0

10mM in DMSO

CAS#: 179461-52-0
Formula: C₁₁H₈FNO₂S
Molecular Weight: 237.25
PubChem CID: 5353866

Item Number

P422187

Grouped product items
SKU	Size	Availability	Price	Qty
P422187-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$210.90

Cell permeable, selective, non-peptidic calpain inhibitor

Basic Description

Synonyms	3-(5-Fluoro-1H-indol-3-yl)-2-mercapto-2-propenoicacid
Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	Cell permeable, selective, non-peptidic calpain inhibitor (K i values are 0.3 and 5 μM for calpain 1 and calpain 2, respectively). Stimulates phagocyte function via hFPR/hFPRL1 activation. Interacts with the Ca 2+ calpain sites.
Storage Temp	Protected from light,Store at -80°C
Shipped In	Ice chest + Ice pads

Associated Targets(Human)

CAPN1 Tchem Calpain-1 catalytic subunit (1 Activities)

Discover Target: CAPN1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CAPN2 Tchem Calpain 2 (185 Activities)

Discover Target: CAPN2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

CAPN1 Calpain 1 (219 Activities)

Discover Target: CAPN1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	(Z)-3-(5-fluoro-1H-indol-3-yl)-2-sulfanylprop-2-enoic acid
INCHI	InChI=1S/C11H8FNO2S/c12-7-1-2-9-8(4-7)6(5-13-9)3-10(16)11(14)15/h1-5,13,16H,(H,14,15)/b10-3-
InChi Key	HWMQHECFXSVZGN-KMKOMSMNSA-N
Canonical SMILES	C1=CC2=C(C=C1F)C(=CN2)C=C(C(=O)O)S
Isomeric SMILES	C1=CC2=C(C=C1F)C(=CN2)/C=C(/C(=O)O)\S
WGK Germany	3
PubChem CID	5353866
Molecular Weight	237.25

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Sensitivity	air and light sensitive

Safety and Hazards(GHS)

WGK Germany	3
RIDADR	NONHforallmodesoftransport

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