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PD 166793 - ≥99%(HPLC), high purity , CAS No.199850-67-4

≥99%(HPLC)

CAS#: 199850-67-4
Formula: C₁₇H₁₈BrNO₄S
Molecular Weight: 412.3
PubChem CID: 9887870

Item Number

P287943

Grouped product items
SKU	Size	Availability	Price
P287943-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$95.90
P287943-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$143.90
P287943-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$328.90
P287943-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$596.90

Broad spectrum MMP inhibitor

Basic Description

Synonyms	NSC16632 \| UNII-U855L3SOXD \| alpha-arylsulfonylamino carboxylate 2S \| (S)-2-(4'-Bromo-biphenyl-4-sulfonylamino-3-methylbutyric acid) \| CS-0028458 \| MMP-2/MMP-3 Inhibitor III, PD166793 - CAS 199850-67-4 \| PD166793 \| PD-166793 \| (2S)-2-[[4-(4-bromophenyl)ph
Specifications & Purity	≥99%(HPLC)
Biochemical and Physiological Mechanisms	Broad spectrum MMP inhibitor. Displays high affinity for MMP-2, -3 and -13 (IC50values are 4, 7 and 8 nM respectively) and exhibits > 750-fold selectivity over MMP-1, -7 and -9. Attenuates left ventricular remodelling and dysfunction in rat model of heart
Storage Temp	Store at -20°C,Desiccated
Shipped In	Ice chest + Ice pads

Associated Targets(Human)

MMP13 Tchem Collagenase 3 (2 Activities)

Discover Target: MMP13

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MMP14 Tchem Matrix metalloproteinase-14 (1 Activities)

Discover Target: MMP14

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MMP2 Tchem 72 kDa type IV collagenase (3 Activities)

Discover Target: MMP2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MMP3 Tchem Stromelysin-1 (3 Activities)

Discover Target: MMP3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MMP3 Tchem Matrix metalloproteinase 3 (3433 Activities)

Discover Target: MMP3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MMP8 Tchem Matrix metalloproteinase 8 (1942 Activities)

Discover Target: MMP8

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MMP14 Tchem Matrix metalloproteinase 14 (1592 Activities)

Discover Target: MMP14

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MMP7 Tchem Matrix metalloproteinase 7 (1073 Activities)

Discover Target: MMP7

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MMP1 Tchem Matrix metalloproteinase-1 (7046 Activities)

Discover Target: MMP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Mmp13 Matrix metalloproteinase 13 (19 Activities)

Discover Target: Mmp13

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mmp2 Matrix metalloproteinase-2 (12 Activities)

Discover Target: Mmp2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mmp9 Matrix metalloproteinase 9 (38 Activities)

Discover Target: Mmp9

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rattus norvegicus (775804 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	(2S)-2-[[4-(4-bromophenyl)phenyl]sulfonylamino]-3-methylbutanoic acid
INCHI	InChI=1S/C17H18BrNO4S/c1-11(2)16(17(20)21)19-24(22,23)15-9-5-13(6-10-15)12-3-7-14(18)8-4-12/h3-11,16,19H,1-2H3,(H,20,21)/t16-/m0/s1
InChi Key	GJOCABIDMCKCEG-INIZCTEOSA-N
Canonical SMILES	CC(C)C(C(=O)O)NS(=O)(=O)C1=CC=C(C=C1)C2=CC=C(C=C2)Br
Isomeric SMILES	CC(C)[C@@H](C(=O)O)NS(=O)(=O)C1=CC=C(C=C1)C2=CC=C(C=C2)Br
PubChem CID	9887870
Molecular Weight	412.3

Certificates

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8 results found

Lot Number	Certificate Type	Date	Item
A2422426	Certificate of Analysis	Dec 21, 2023	P287943
A2422427	Certificate of Analysis	Dec 21, 2023	P287943
A2422428	Certificate of Analysis	Dec 21, 2023	P287943
A2422429	Certificate of Analysis	Dec 21, 2023	P287943
A2422430	Certificate of Analysis	Dec 21, 2023	P287943
A2422431	Certificate of Analysis	Dec 21, 2023	P287943
A2422432	Certificate of Analysis	Dec 21, 2023	P287943
A2422433	Certificate of Analysis	Dec 21, 2023	P287943

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