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PD-166866 - 10mM in DMSO, high purity , CAS No.192705-79-6
Basic Description Synonyms 192705-79-6 | PD-166866 | PD166866 | PD 166866 | 1-[2-amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea | 1-(2-Amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)-3-(tert-butyl)urea | CHEMBL299763 | NA856793UT | 1-(2-Amino-6-(3,5-dimethoxyp Specifications & Purity 10mM in DMSO Biochemical and Physiological Mechanisms PD-166866 is a selective inhibitor of the FGF-1 receptor tyrosine kinase (FGFR1) with IC50 = 55 nM, and no effect on c-Src, PDGFR-b, EGFR or insulin receptor tyrosine kinases or MEK, PKC, and CDK4. Storage Temp Store at -80°C Shipped In Ice chest + Ice pads
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name 1-[2-amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea INCHI InChI=1S/C20H24N6O3/c1-20(2,3)26-19(27)25-17-15(8-12-10-22-18(21)24-16(12)23-17)11-6-13(28-4)9-14(7-11)29-5/h6-10H,1-5H3,(H4,21,22,23,24,25,26,27) InChi Key NHJSWORVNIOXIT-UHFFFAOYSA-N Canonical SMILES CC(C)(C)NC(=O)NC1=C(C=C2C=NC(=NC2=N1)N)C3=CC(=CC(=C3)OC)OC Isomeric SMILES CC(C)(C)NC(=O)NC1=C(C=C2C=NC(=NC2=N1)N)C3=CC(=CC(=C3)OC)OC WGK Germany 3 PubChem CID 5328127 Molecular Weight 396.44
Safety and Hazards(GHS) Pictogram(s) GHS06 Signal Danger Hazard Statements H301: Toxic if swallowed
H413: May cause long lasting harmful effects to aquatic life
Precautionary Statements P301+P310: IF SWALLOWED: Immediately call a POISON CENTER/doctor/...
WGK Germany 3
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