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PD 168077 maleate - 97%, high purity , CAS No.630117-19-0

≥97%

CAS#: 630117-19-0
Formula: C₂₀H₂₂N₄O.C₄H₄O₄
Molecular Weight: 450.49
PubChem CID: 11957665
PubChem SID: 488197809

Item Number

P286721

Grouped product items
SKU	Size	Availability	Price
P286721-5mg	5mg	In stock	$98.90
P286721-10mg	10mg	In stock	$147.90
P286721-25mg	25mg	In stock	$305.90
P286721-50mg	50mg	In stock	$513.90
P286721-100mg	100mg	Available within 1-2 weeks(?) Item is derived from our semi-finished stock and is processed in 1-2 weeks.	$870.90

High affinity, selective D4agonist

Basic Description

Synonyms	N-((4-(2-Cyanophenyl)-1-piperazinyl)methyl)-3-methylbenzamide (2Z)-2-butenedioate (1:1) \| HY-21098A \| N-(Methyl-4-(2-cyanophenyl)piperazinyl-3-methylbenzamide maleate \| AKOS024256763 \| PD168077 Maleate \| PD-168077 maleate \| PD 168,077 maleate \| HMS3650G07
Specifications & Purity	≥97%
Biochemical and Physiological Mechanisms	A potent D4dopamine receptor agonist (Ki= 8.7 nM) with > 400-fold selectivity over D2and > 300-fold selectivity versus D3subtypes respectively. Induces synaptic translocation of CaMK II to postsynaptic sites in cultured prefrontal cortical neurons. Centra
Storage Temp	Store at -20°C,Desiccated
Shipped In	Ice chest + Ice pads

Associated Targets(Human)

THRB Tclin Thyroid hormone receptor beta-1 (7926 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

POLH Tchem DNA polymerase eta (21678 Activities)

Discover Target: POLH

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

Discover Target: EHMT2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

LMNA Tbio Prelamin-A/C (36751 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

BLM Tchem Bloom syndrome protein (4248 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GMNN Tbio Geminin (128009 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PMP22 Tbio Peripheral myelin protein 22 (699 Activities)

Discover Target: PMP22

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

APOBEC3F Tbio DNA dC->dU-editing enzyme APOBEC-3F (14861 Activities)

Discover Target: APOBEC3F

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)

Discover Target: Txnrd1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

Pubchem Sid	488197809
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488197809
IUPAC Name	(Z)-but-2-enedioic acid;N-[[4-(2-cyanophenyl)piperazin-1-yl]methyl]-3-methylbenzamide
INCHI	InChI=1S/C20H22N4O.C4H4O4/c1-16-5-4-7-17(13-16)20(25)22-15-23-9-11-24(12-10-23)19-8-3-2-6-18(19)14-21;5-3(6)1-2-4(7)8/h2-8,13H,9-12,15H2,1H3,(H,22,25);1-2H,(H,5,6)(H,7,8)/b;2-1-
InChi Key	NAEUGRPISCANHO-BTJKTKAUSA-N
Canonical SMILES	CC1=CC(=CC=C1)C(=O)NCN2CCN(CC2)C3=CC=CC=C3C#N.C(=CC(=O)O)C(=O)O
Isomeric SMILES	CC1=CC(=CC=C1)C(=O)NCN2CCN(CC2)C3=CC=CC=C3C#N.C(=C\C(=O)O)\C(=O)O
PubChem CID	11957665
Molecular Weight	450.49

Certificates

Certificate of Analysis(COA)

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10 results found

Lot Number	Certificate Type	Date	Item
D2308363	Certificate of Analysis	Feb 11, 2022	P286721
D2308364	Certificate of Analysis	Feb 11, 2022	P286721
D2308365	Certificate of Analysis	Feb 11, 2022	P286721
D2308366	Certificate of Analysis	Feb 11, 2022	P286721
D2308401	Certificate of Analysis	Feb 11, 2022	P286721
D2308404	Certificate of Analysis	Feb 11, 2022	P286721
D2308405	Certificate of Analysis	Feb 11, 2022	P286721
D2308406	Certificate of Analysis	Feb 11, 2022	P286721
D2308407	Certificate of Analysis	Feb 11, 2022	P286721
D2308408	Certificate of Analysis	Feb 11, 2022	P286721

Safety and Hazards(GHS)

Signal	Warning
Hazard Statements	H302:Harmful if swallowed
Precautionary Statements	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection.

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