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PD 168368 - ≥96%, high purity , CAS No.204066-82-0, Antagonist of BB 1 receptor;Antagonist of BB 2 receptor
a potent NMB (Neuromedin B) receptor antagonist that displays ~40-fold selectivity over the gastrin-releasing peptide receptor.
Basic Description Specifications & Purity Moligand™, ≥96% Storage Temp Store at 2-8°C Shipped In Wet ice Grade Moligand™ Action Type ANTAGONIST Mechanism of action Antagonist of BB 1 receptor;Antagonist of BB 2 receptor Note It is recommend to use solutions containing sc-204166 within the same day they are made. To store a solution, aliquot into usable amounts and store at -20°C for up to two weeks. Product Description PD 168368 is a Neuromedin B antagonist displaying ~40-fold selectivity over the gastrin-releasing peptide receptor (GRP-R, BB2). PD 168368 also shows >300-fold selectivity over BRS-R (BB3). PD 168368 antagonizes neuromedin B-stimulated Ca|2+|release. Simultaneously, PD 168368 inhibits proliferation of rat glioma cells.
Product Properties pKa pKₐ: 11.6 (Predicted), pKₐ: 5.65 (Predicted) Ki Data NMBR: Ki= 0.15 nM (human); GRPR: Ki= 17 nM (human)
Names and Identifiers IUPAC Name (2S)-3-(1H-indol-3-yl)-2-methyl-2-[(4-nitrophenyl)carbamoylamino]-N-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide INCHI InChI=1S/C31H34N6O4/c1-30(19-22-20-33-26-10-4-3-9-25(22)26,36-29(39)35-23-12-14-24(15-13-23)37(40)41)28(38)34-21-31(16-6-2-7-17-31)27-11-5-8-18-32-27/h3-5,8-15,18,20,33H,2,6-7,16-17,19,21H2,1H3,(H,34,38)(H2,35,36,39)/t30-/m0/s1 InChi Key AFDXUTWMFMAQJO-PMERELPUSA-N Canonical SMILES CC(CC1=CNC2=CC=CC=C21)(C(=O)NCC3(CCCCC3)C4=CC=CC=N4)NC(=O)NC5=CC=C(C=C5)[N+](=O)[O-] Isomeric SMILES C[C@](CC1=CNC2=CC=CC=C21)(C(=O)NCC3(CCCCC3)C4=CC=CC=N4)NC(=O)NC5=CC=C(C=C5)[N+](=O)[O-] PubChem CID 9937534 MeSH Entry Terms PD 168368;PD168368 Molecular Weight 554.65
Chemical and Physical Properties Solubility Soluble in DMSO (100 mM). Refractive Index n20D1.66 (Predicted) Boil Point(°C) ~819.7° C at 760 mmHg (Predicted)
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