PD 90780 - ≥98%(HPLC), high purity , CAS No.77422-99-2

Item Number

P287783

Grouped product items
SKU	Size	Availability	Price
P287783-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$135.90
P287783-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$208.90
P287783-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$468.90
P287783-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$846.90
P287783-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,523.90

Inhibits NGF binding to p75NTR

Basic Description

Synonyms	7-(Benzoylamino)-4,9-dihydro-4-methyl-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylic acid
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	A nonpeptide inhibitor of NGF binding to p75NTR(IC50~ 1μM in CHO cells); binds NGF, not p75NTR. Affinity maybe altered by the presence of TrkA receptors. Neuroprotective.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads

Associated Targets(Human)

NGFR Tclin Tumor necrosis factor receptor superfamily member 16 (1 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NGFR Tclin Low affinity neurotrophin receptor p75NTR (32 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NTRK1 Tclin Nerve growth factor receptor Trk-A (7922 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	7-benzamido-4-methyl-9-oxopyrazolo[5,1-b]quinazoline-2-carboxylic acid
INCHI	InChI=1S/C19H14N4O4/c1-22-15-8-7-12(20-17(24)11-5-3-2-4-6-11)9-13(15)18(25)23-16(22)10-14(21-23)19(26)27/h2-10H,1H3,(H,20,24)(H,26,27)
InChi Key	IAZAGXDMMVWYKF-UHFFFAOYSA-N
Canonical SMILES	CN1C2=C(C=C(C=C2)NC(=O)C3=CC=CC=C3)C(=O)N4C1=CC(=N4)C(=O)O
Isomeric SMILES	CN1C2=C(C=C(C=C2)NC(=O)C3=CC=CC=C3)C(=O)N4C1=CC(=N4)C(=O)O
PubChem CID	9885305
Molecular Weight	362.34

Certificates

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5 results found

Lot Number	Certificate Type	Date	Item
D2301934	Certificate of Analysis	Feb 03, 2023	P287783
D2301936	Certificate of Analysis	Feb 03, 2023	P287783
D2301937	Certificate of Analysis	Feb 03, 2023	P287783
D2301938	Certificate of Analysis	Feb 03, 2023	P287783
D2301942	Certificate of Analysis	Feb 03, 2023	P287783

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Basic Description