PD123319 - 98%, high purity , CAS No.130663-39-7, Antagonist of AT 2 receptor

Item Number
P129377
Grouped product items
SKUSizeAvailabilityPrice Qty
P129377-1mg
1mg
In stock
$36.90
P129377-5mg
5mg
In stock
$139.90
P129377-10mg
10mg
In stock
$251.90
P129377-25mg
25mg
In stock
$442.90
P129377-50mg
50mg
In stock
$796.90
P129377-100mg
100mg
In stock
$1,434.90

Basic Description

SynonymsA13201 | PD123319 | PD-123319 | (6S)-1-[(4-dimethylamino-3-methylphenyl)methyl]-5-[2,2-di(phenyl)acetyl]-6,7-dihydro-4H-imidazo[5,4-d]pyridine-6-carboxylic acid | BDBM50282396 | (6s)1-[[4-(dimethylamino)-3-methylphenyl]methyl]-5-(diphenylacetyl)-4,5,6,7-t
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsPD 123319 is shown to discriminate between two subclasses of AII receptors in many different tissues. 125I-AII specifically label two classes of binding sites for AII in a membrane preparation of bovine adrenal glomerulosa cells. The first class (DuP-753
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeANTAGONIST
Mechanism of actionAntagonist of AT 2 receptor
Product Description

product description:

PD 123319 (ditrifluoroacetate) is a potent, selective AT2 angiotensin II receptor antagonist with IC50 of 34 nM.

Associated Targets(Human)

AGTR1 Tclin Type-1 angiotensin II receptor (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
AGTR2 Tchem Type-2 angiotensin II receptor (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name (6S)-1-[[4-(dimethylamino)-3-methylphenyl]methyl]-5-(2,2-diphenylacetyl)-6,7-dihydro-4H-imidazo[4,5-c]pyridine-6-carboxylic acid
INCHI InChI=1S/C31H32N4O3/c1-21-16-22(14-15-26(21)33(2)3)18-34-20-32-25-19-35(28(31(37)38)17-27(25)34)30(36)29(23-10-6-4-7-11-23)24-12-8-5-9-13-24/h4-16,20,28-29H,17-19H2,1-3H3,(H,37,38)/t28-/m0/s1
InChi Key YSTVFDAKLDMYCR-NDEPHWFRSA-N
Canonical SMILES CC1=C(C=CC(=C1)CN2C=NC3=C2CC(N(C3)C(=O)C(C4=CC=CC=C4)C5=CC=CC=C5)C(=O)O)N(C)C
Isomeric SMILES CC1=C(C=CC(=C1)CN2C=NC3=C2C[C@H](N(C3)C(=O)C(C4=CC=CC=C4)C5=CC=CC=C5)C(=O)O)N(C)C
PubChem CID 5311345
Molecular Weight 508.61

Certificates

Certificate of Analysis(COA)

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12 results found

Lot NumberCertificate TypeDateItem
H2312328Certificate of AnalysisJun 17, 2023 P129377
H2312329Certificate of AnalysisJun 17, 2023 P129377
H2312334Certificate of AnalysisJun 17, 2023 P129377
H2312335Certificate of AnalysisJun 17, 2023 P129377
H2312338Certificate of AnalysisJun 17, 2023 P129377
H2312341Certificate of AnalysisJun 17, 2023 P129377
H2312343Certificate of AnalysisJun 17, 2023 P129377
H2312344Certificate of AnalysisJun 17, 2023 P129377
H2312345Certificate of AnalysisJun 17, 2023 P129377
H2312349Certificate of AnalysisJun 17, 2023 P129377
H2312352Certificate of AnalysisJun 17, 2023 P129377
H2314339Certificate of AnalysisJun 17, 2023 P129377

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Chemical and Physical Properties

SolubilityDMSO 100 mg/mL Water 100 mg/mL Ethanol 100 mg/mL

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