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PD153035 HCl - ≥98%(HPLC), high purity , CAS No.183322-45-4

≥98%(HPLC)

CAS#: 183322-45-4
Formula: C₁₆H₁₄BrN₃O₂·HCl
Molecular Weight: 396.67
MDL number: MFCD01074805
PubChem CID: 11246488

Item Number

P129384

Grouped product items
SKU	Size	Availability	Price
P129384-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$76.90
P129384-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$294.90
P129384-250mg	250mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,327.90

EGFR-kinase inhibitor

View related series

EGFR JAK/STAT Signaling Protein Tyrosine Kinase/RTK Quinazolines Six-Membered Heterocyclic Compounds

Basic Description

Synonyms	J-518170 \| s1079 \| N-(3-bromophenyl)-6,7-dimethoxyquinazolin-4-aminium chloride \| SR-01000597835 \| BS-16156 \| ZM252868 \| PD153035 HCl (SU-5271, AG1517) \| PD153035 (Hydrochloride);SU-5271 (Hydrochloride); AG1517 (Hydrochloride); ZM 252868 (Hydrochloride) \|
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	An extremely potent inhibitor of epidermal growth factor (EGF) receptor tyrosine kinase, with an IC50of 25 pM. Inhibits other purified tyrosine kinases only at micromolar or higher concentrations.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Note	卖完停产，不再备货
Product Description	PD153035 is a potent and specific inhibitor of EGFR with Ki and IC50 of 5.2 pM and 29 pM; little effect noted against PGDFR, FGFR, CSF-1, InsR and Src. A potent inhibitor of epidermal growth factor (EGF) receptor tyrosine kinase

Associated Targets(Human)

EGFR Tclin Epidermal growth factor receptor (2 Activities)

Discover Target: EGFR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

EGFR Tclin Epidermal growth factor receptor erbB1 (33727 Activities)

Discover Target: EGFR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ERBB2 Tclin Receptor protein-tyrosine kinase erbB-2 (7851 Activities)

Discover Target: ERBB2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ERBB4 Tclin Receptor protein-tyrosine kinase erbB-4 (2748 Activities)

Discover Target: ERBB4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MCF7 (126967 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	N-(3-bromophenyl)-6,7-dimethoxyquinazolin-4-amine;hydrochloride
INCHI	InChI=1S/C16H14BrN3O2.ClH/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11;/h3-9H,1-2H3,(H,18,19,20);1H
InChi Key	ZJOKWAWPAPMNIM-UHFFFAOYSA-N
Canonical SMILES	COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)Br)OC.Cl
Isomeric SMILES	COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)Br)OC.Cl
WGK Germany	3
PubChem CID	11246488
Molecular Weight	396.67

Lot Number

Certificate Type

Date

Item

F1510078

Certificate of Analysis

May 11, 2023

P129384

Solubility

Solvent:DMSO, Max Conc. mg/mL: 3.97, Max Conc. mM: 10 with gentle warming

Sensitivity

Heat Sensitive

Melt Point(°C)

265 °C

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS05, GHS07
Signal	Danger
Hazard Statements	H315:Causes skin irritation H335:May cause respiratory irritation H301:Toxic if swallowed H318:Causes serious eye damage
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P317:Get emergency medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	3

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PD153035 HCl - ≥98%(HPLC), high purity , CAS No.183322-45-4

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

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