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PD184352 (CI-1040) - ≥98%, high purity , Dual specificity mitogen-activated protein kinase kinase 2 inhibitor, CAS No.212631-79-3, Dual specificity mitogen-activated protein kinase kinase 2 inhibitor
Basic Description Synonyms 212631-79-3|CI-1040|PD184352|PD 184352|PD-184352|2-(2-chloro-4-iodophenylamino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide|PD184352 (CI-1040)|CI 1040|2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide|CI1040|PD 184,352|2-((2-Chlor Specifications & Purity ≥98% Legal Information Sold for only research purposes Storage Temp Store at -20°C Shipped In Dry ice Grade Moligand™ Action Type ALLOSTERIC MODULATOR, INHIBITOR Mechanism of action Dual specificity mitogen-activated protein kinase kinase 2 inhibitor Product Description PD184352 (CI-1040) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM, 100-fold more selective for MEK1/2 than MEK5
Names and Identifiers IUPAC Name 2-(2-chloro-4-iodoanilino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide INCHI InChI=1S/C17H14ClF2IN2O2/c18-12-7-10(21)3-6-14(12)22-16-11(4-5-13(19)15(16)20)17(24)23-25-8-9-1-2-9/h3-7,9,22H,1-2,8H2,(H,23,24) InChi Key GFMMXOIFOQCCGU-UHFFFAOYSA-N Canonical SMILES C1CC1CONC(=O)C2=C(C(=C(C=C2)F)F)NC3=C(C=C(C=C3)I)Cl Isomeric SMILES C1CC1CONC(=O)C2=C(C(=C(C=C2)F)F)NC3=C(C=C(C=C3)I)Cl WGK Germany 3 PubChem CID 6918454 Molecular Weight 478.66
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 47.87, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 11.97, Max Conc. mM: 25
Safety and Hazards(GHS) Pictogram(s) GHS09 Signal Warning Hazard Statements H400: Very toxic to aquatic life
Precautionary Statements P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
P391: Collect spillage.
WGK Germany 3
References 1. Sebolt-Leopold JS, Dudley DT, Herrera R, Van Becelaere K, Wiland A, Gowan RC, Tecle H, Barrett SD, Bridges A, Przybranowski S et al. . (1999) Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo.. Nat Med, 5 (7): (810-6). [PMID:10395327 ] 2. Davies SP, Reddy H, Caivano M, Cohen P. (2000) Specificity and mechanism of action of some commonly used protein kinase inhibitors.. Biochem J, 351 (Pt 1): (95-105). [PMID:10998351 ]
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H2206149