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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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C125418-25mg | 25mg | In stock | $195.90 | |
C125418-100mg | 100mg | In stock | $510.90 | |
C125418-250mg | 250mg | In stock | $1,149.90 | |
C125418-500mg | 500mg | In stock | $2,069.90 |
Selective MEK inhibitor
Synonyms | 212631-79-3 | CI-1040 | PD184352 | PD 184352 | PD-184352 | 2-(2-chloro-4-iodophenylamino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide | PD184352 (CI-1040) | CI 1040 | 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide | CI1040 | PD 184,352 | 2-((2-Chlor |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Selective MEK inhibitor (Ki= 300 nMin vitro). Suppresses FGF-mediated angiogenesisin vivoand decreases VEGF expression. Enhances the therapeutic efficacy oftaxol in vivo. Orally active. |
Legal Information | Sold for only research purposes |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | ALLOSTERIC MODULATOR, INHIBITOR |
Mechanism of action | Dual specificity mitogen-activated protein kinase kinase 2 inhibitor |
Product Description | PD184352 (CI-1040) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM, 100-fold more selective for MEK1/2 than MEK5 |
ALogP | 5.6 |
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IUPAC Name | 2-(2-chloro-4-iodoanilino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide |
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INCHI | InChI=1S/C17H14ClF2IN2O2/c18-12-7-10(21)3-6-14(12)22-16-11(4-5-13(19)15(16)20)17(24)23-25-8-9-1-2-9/h3-7,9,22H,1-2,8H2,(H,23,24) |
InChi Key | GFMMXOIFOQCCGU-UHFFFAOYSA-N |
Canonical SMILES | C1CC1CONC(=O)C2=C(C(=C(C=C2)F)F)NC3=C(C=C(C=C3)I)Cl |
Isomeric SMILES | C1CC1CONC(=O)C2=C(C(=C(C=C2)F)F)NC3=C(C=C(C=C3)I)Cl |
WGK Germany | 3 |
PubChem CID | 6918454 |
Molecular Weight | 478.66 |
CAS Registry No. | 212631-79-3 |
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DiscoveRx TREEspot | CI-1040| |
PubChem CID | 6918454 |
ChEMBL Ligand | CHEMBL105442 |
Reactome Reaction | R-HSA-9657606 |
Reactome Drug | R-ALL-9657563 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
H2206149 | Certificate of Analysis | May 11, 2024 | C125418 |
H2206150 | Certificate of Analysis | May 11, 2024 | C125418 |
H2206151 | Certificate of Analysis | May 11, 2024 | C125418 |
H2206152 | Certificate of Analysis | May 11, 2024 | C125418 |
Solubility | Solvent:DMSO, Max Conc. mg/mL: 47.87, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 11.97, Max Conc. mM: 25 |
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Pictogram(s) | GHS09 |
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Signal | Warning |
Hazard Statements | H400:Very toxic to aquatic life |
Precautionary Statements | P273:Avoid release to the environment. P501:Dispose of contents/container to ... P391:Collect spillage. |
WGK Germany | 3 |
1. Sebolt-Leopold JS, Dudley DT, Herrera R, Van Becelaere K, Wiland A, Gowan RC, Tecle H, Barrett SD, Bridges A, Przybranowski S et al.. (1999) Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo.. Nat Med, 5 (7): (810-6). [PMID:10395327] |
2. Davies SP, Reddy H, Caivano M, Cohen P. (2000) Specificity and mechanism of action of some commonly used protein kinase inhibitors.. Biochem J, 351 (Pt 1): (95-105). [PMID:10998351] |