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PDE4 inhibitor 16 , CAS No.P612664, Inhibitor of phosphodiesterase 10A;Inhibitor of phosphodiesterase 4D;Inhibitor of phosphodiesterase 6C

Moligand™

PubChem CID: 138393292

Item Number

P612664

Grouped product items
SKU	Size	Availability	Price	Qty
P612664-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,000.90
P612664-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

View related series

phosphodiesterase 10A Inhibitor phosphodiesterase 4D Inhibitor phosphodiesterase 6C Inhibitor

Specifications & Purity

Moligand™

Grade

Moligand™

Action Type

INHIBITOR

Mechanism of action

Inhibitor of phosphodiesterase 10A;Inhibitor of phosphodiesterase 4D;Inhibitor of phosphodiesterase 6C

Associated Targets

DRD1 Tclin D(1A) dopamine receptor 0 Activities

Discover Target: DRD1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

DRD2 Tclin D(2) dopamine receptor 0 Activities

Discover Target: DRD2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDE11A Tchem Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A 0 Activities

Discover Target: PDE11A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDE8A Tclin High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A 0 Activities

Discover Target: PDE8A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDE7A Tclin High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A 0 Activities

Discover Target: PDE7A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDE10A Tclin cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 1 Activities

Discover Target: PDE10A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDE4D Tclin cAMP-specific 3',5'-cyclic phosphodiesterase 4D 1 Activities

Discover Target: PDE4D

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDE9A Tchem High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A 0 Activities

Discover Target: PDE9A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDE3A Tclin cGMP-inhibited 3',5'-cyclic phosphodiesterase A 0 Activities

Discover Target: PDE3A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDE5A Tclin cGMP-specific 3',5'-cyclic phosphodiesterase 0 Activities

Discover Target: PDE5A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDE4A Tclin cAMP-specific 3',5'-cyclic phosphodiesterase 4A 0 Activities

Discover Target: PDE4A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDE1A Tclin Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0 Activities

Discover Target: PDE1A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDE6C Tclin Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' 0 Activities

Discover Target: PDE6C

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDE2A Tclin cGMP-dependent 3',5'-cyclic phosphodiesterase 0 Activities

Discover Target: PDE2A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 0 Activities

Discover Target: KCNH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(S)-6,7-Dimethoxy-1-(2-(6-methyl-1H-indol-3-yl)ethyl)-3,4-dihydroisoquinoline-2(1H)-carbaldehyde
INCHI	InChI=1S/C23H26N2O3/c1-15-4-6-18-17(13-24-20(18)10-15)5-7-21-19-12-23(28-3)22(27-2)11-16(19)8-9-25(21)14-26/h4,6,10-14,21,24H,5,7-9H2,1-3H3/t21-/m0/s1
InChi Key	OIDQRHGTWLIKKZ-NRFANRHFSA-N
Canonical SMILES	O=CN1CCc2c([C@@H]1CCc1c[nH]c3c1ccc(c3)C)cc(c(c2)OC)OC
Isomeric SMILES	CC1=CC2=C(C=C1)C(=CN2)CC[C@H]3C4=CC(=C(C=C4CCN3C=O)OC)OC
PubChem CID	138393292

RCSB PDB Ligand

AKO

PubChem CID

138393292

References

1. Zhang X, Dong G, Li H, Chen W, Li J, Feng C, Gu Z, Zhu F, Zhang R, Li M et al.. (2019) Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent.. J Med Chem, 62 (11): (5579-5593). [PMID:31099559]

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