Pefloxacin - 98%, high purity , Topoisomerase IV inhibitor, CAS No.70458-92-3, Topoisomerase IV inhibitor

14 Citations
Item Number
P304448
Grouped product items
SKUSizeAvailabilityPrice Qty
P304448-10mg
10mg
In stock
$19.90
P304448-25mg
25mg
In stock
$40.90
P304448-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$135.90
P304448-250mg
250mg
In stock
$304.90
P304448-1g
1g
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,095.90

Basic Description

Synonyms1584RB | 1589-RB | Pefloxacin [USAN:INN:BAN] | SBI-0206758.P001 | SMR000273037 | D02306 | Oprea1_063677 | 1-ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid | 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-methylpiperazinyl)quinoline-3-
Specifications & PurityMoligand™, ≥98%
Storage TempStore at 2-8°C
Shipped InWet ice
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionTopoisomerase IV inhibitor

Product Properties

ALogP0.3

Associated Targets(non-human)

gyrB DNA gyrase subunit B (290 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Agtr2 Angiotensin II type 2 (AT-2) receptor (803 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mc4r Melanocortin receptor 4 (1205 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ltc4s Leukotriene C4 synthase (1 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Sigmar1 Sigma opioid receptor (160 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Npy1r Neuropeptide Y receptor type 1 (8 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cckar Cholecystokinin A receptor (90 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pde4d Phosphodiesterase 4D (4 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Nos2 Nitric oxide synthase, inducible (3573 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mapk1 MAP kinase ERK2 (650 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mmp9 Matrix metalloproteinase 9 (38 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Streptococcus pneumoniae (31063 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium yoelii yoelii (73 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pseudomonas aeruginosa (123386 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Enterobacter cloacae (7976 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Klebsiella pneumoniae (43867 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Proteus vulgaris (5823 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Providencia rettgeri (925 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Staphylococcus hominis (482 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Acinetobacter baumannii (41033 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Klebsiella aerogenes (4963 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Escherichia coli (133304 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Serratia marcescens (3237 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Streptococcus pyogenes (16140 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Bacillus subtilis (32866 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mycobacterium tuberculosis (203094 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Enterococcus faecalis (29875 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
L1210 (27553 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
V79 (1637 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasma (328 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
gyrB DNA gyrase (2092 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mycobacterium leprae (477 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Glra2 Glycine receptor (1745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name 1-ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid
INCHI InChI=1S/C17H20FN3O3/c1-3-20-10-12(17(23)24)16(22)11-8-13(18)15(9-14(11)20)21-6-4-19(2)5-7-21/h8-10H,3-7H2,1-2H3,(H,23,24)
InChi Key FHFYDNQZQSQIAI-UHFFFAOYSA-N
Canonical SMILES CCN1C=C(C(=O)C2=CC(=C(C=C21)N3CCN(CC3)C)F)C(=O)O
Isomeric SMILES CCN1C=C(C(=O)C2=CC(=C(C=C21)N3CCN(CC3)C)F)C(=O)O
PubChem CID 51081
Molecular Weight 333.36

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

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Lot NumberCertificate TypeDateItem
L2304031Certificate of AnalysisNov 08, 2021 P304448

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

H302:Harmful if swallowed

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P270:Do not eat, drink or smoke when using this product.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P330:Rinse mouth.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P301+P317:IF SWALLOWED: Get medical help.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

Related Documents

Citations of This Product

1. Yanzhuo Zhang, Yutai Sun, Rui He, Jing Zhao, Jiqin Wang, Tonghuan Yu, Xiaozhuan Zhang, Alexandr V. Bildyukevich.  (2024)  Effects of excess sludge composting process, environmentally persistent free radicals, and microplastics on antibiotics degradation efficiency of aging biochar.  BIORESOURCE TECHNOLOGY,  393  (15): (130070).  [PMID:37984667]
2. Xuan Wan, Haohao Du, Du Tuo, Xiaoman Qi, Tianyu Wang, Jingtao Wu, Guangli Li.  (2023)  UiO-66/Carboxylated Multiwalled Carbon Nanotube Composites for Highly Efficient and Stable Voltammetric Sensors for Gatifloxacin.  ACS Applied Nano Materials,  (20): (19403–19413).  [PMID:15378032]
3. Guangli Li, Xuan Wan, Yonghui Xia, Du Tuo, Xiaoman Qi, Tianyu Wang, Mohammad Mehmandoust, Nevin Erk, Quanguo He, Qing Li.  (2023)  Lamellar α-Zirconium Phosphate Nanoparticles Supported on N-Doped Graphene Nanosheets as Electrocatalysts for the Detection of Levofloxacin.  ACS Applied Nano Materials,  (18): (17040–17052).  [PMID:11485546]
4. Han Yin, Ziyi Zhen, Weijie Ning, Lu Zhang, Yuhong Xiang, Nengsheng Ye.  (2023)  Three-dimensional fluorinated covalent organic frameworks coated capillary for the separation of fluoroquinolones by capillary electrochromatography.  JOURNAL OF CHROMATOGRAPHY A,  1706  (464234).  [PMID:37523908]
5. L. Wang, D. Wang, Y. Tao, J. Wang, M. Tian, Q. Liu, Y. Yang, Y. Zou, F. Ke, X. Guo, X. Li, D. Gao.  (2023)  Phenylboronic acid functionalized high-crystallinity fluorescent covalent organic framework act as a sensing platform with dual performance for rifamycin antibiotics and water and adsorbent for rifamycin antibiotics.  Materials Today Chemistry,  32  (101647).  [PMID:]
6. Chang Liu, Hong Lin, Limin Cao, Kaiqiang Wang, Jianxin Sui.  (2023)  Characterization, specific recognition, and the performance in fish matrix of a shark-derived single-domain antibody against enrofloxacin.  TALANTA,  265  (124852).  [PMID:37385191]
7. Changxing Wang, Feifei Qin, Siyuan Tang, Xiameng Li, Tingting Li, Guoqiang Guo, Chenjie Gu, Xu Wang, Da Chen.  (2023)  Construction of graphene quantum dots ratiometric fluorescent probe by intermolecular electron transfer effect for intelligent and real-time visual detection of ofloxacin and its L-isomer in daily drink.  FOOD CHEMISTRY,  411  (135514).  [PMID:36724609]
8. Rong Shen, Yichang Yu, Qinfang Liu, Ruili Wang, Rong Lan, Hui Feng, Ran Yu, Lihua Jin, Ye Li.  (2022)  Toxic Effects and Mechanism of Pefloxacin on the Early Life Stage of Zebrafish (Danio rerio).  Water,  14  (23): (3857).  [PMID:]
9. Ruizhen Li, Yu Hu, Lijun Du, Jiawen Li, Jigang Yuan, Xingyong Liu.  (2022)  In-situ photoelectrocatalytical formation of sulfate radicals on BiPO4 modified carbon paper electrode in sodium sulfate electrolyte for high efficient degradation of pefloxacin.  JOURNAL OF MOLECULAR STRUCTURE,  1268  (133547).  [PMID:]
10. Lishan Zhang, Zujie Yao, Huamei Tang, Qingli Song, Huanhuan Song, Jindong Yao, Zhen Li, Xiaofang Xie, Yuexu Lin, Xiangmin Lin.  (2022)  The Lysine Acetylation Modification in the Porin Aha1 of Aeromonas hydrophila Regulates the Uptake of Multidrug Antibiotics.  MOLECULAR & CELLULAR PROTEOMICS,  21  (9):   [PMID:35605723]
11. Jin'ai Chen, Yuting Jin, Taotao Ren, Shuo Wang, Xianghong Wang, Fuyuan Zhang, Yiwei Tang.  (2022)  A novel terbium (III) and aptamer-based probe for label-free detection of three fluoroquinolones in honey and water samples.  FOOD CHEMISTRY,  386  (132751).  [PMID:35334319]
12. Huang Hongli, Zheng Yongxin, Wei Dongning, Yang Guang, Peng Xin, Fan Lingjia, Luo Lin, Zhou Yaoyu.  (2022)  Efficient removal of pefloxacin from aqueous solution by acid–alkali modified sludge-based biochar: adsorption kinetics, isotherm, thermodynamics, and mechanism.  ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH,  29  (28): (43201-43211).  [PMID:35091955]
13. Yanzhuo Zhang, Mengqi Xu, Rui He, Jing Zhao, Wei Kang, Jinghua Lv.  (2022)  Effect of pyrolysis temperature on the activated permonosulfate degradation of antibiotics in nitrogen and sulfur-doping biochar: Key role of environmentally persistent free radicals.  CHEMOSPHERE,  294  (133737).  [PMID:35090846]
14. Wenying Fan,Man He,Xiaoran Wu,Beibei Chen,Bin Hu.  (2015-10-05)  Graphene oxide/polyethyleneglycol composite coated stir bar for sorptive extraction of fluoroquinolones from chicken muscle and liver..  Journal of chromatography. A,  1418  (36-44).  [PMID:26433263]

References

1. Yourassowsky E, Van der Linden MP, Crokaert F, Glupczynski Y.  (1986)  In-vitro activity of pefloxacin compared to other antibiotics..  J Antimicrob Chemother,  17 Suppl B  (3): (19-28).  [PMID:3086279]
2. Yanzhuo Zhang, Yutai Sun, Rui He, Jing Zhao, Jiqin Wang, Tonghuan Yu, Xiaozhuan Zhang, Alexandr V. Bildyukevich.  (2024)  Effects of excess sludge composting process, environmentally persistent free radicals, and microplastics on antibiotics degradation efficiency of aging biochar.  BIORESOURCE TECHNOLOGY,  393  (15): (130070).  [PMID:37984667]
3. Xuan Wan, Haohao Du, Du Tuo, Xiaoman Qi, Tianyu Wang, Jingtao Wu, Guangli Li.  (2023)  UiO-66/Carboxylated Multiwalled Carbon Nanotube Composites for Highly Efficient and Stable Voltammetric Sensors for Gatifloxacin.  ACS Applied Nano Materials,  (20): (19403–19413).  [PMID:15378032]
4. Guangli Li, Xuan Wan, Yonghui Xia, Du Tuo, Xiaoman Qi, Tianyu Wang, Mohammad Mehmandoust, Nevin Erk, Quanguo He, Qing Li.  (2023)  Lamellar α-Zirconium Phosphate Nanoparticles Supported on N-Doped Graphene Nanosheets as Electrocatalysts for the Detection of Levofloxacin.  ACS Applied Nano Materials,  (18): (17040–17052).  [PMID:11485546]
5. Han Yin, Ziyi Zhen, Weijie Ning, Lu Zhang, Yuhong Xiang, Nengsheng Ye.  (2023)  Three-dimensional fluorinated covalent organic frameworks coated capillary for the separation of fluoroquinolones by capillary electrochromatography.  JOURNAL OF CHROMATOGRAPHY A,  1706  (464234).  [PMID:37523908]
6. L. Wang, D. Wang, Y. Tao, J. Wang, M. Tian, Q. Liu, Y. Yang, Y. Zou, F. Ke, X. Guo, X. Li, D. Gao.  (2023)  Phenylboronic acid functionalized high-crystallinity fluorescent covalent organic framework act as a sensing platform with dual performance for rifamycin antibiotics and water and adsorbent for rifamycin antibiotics.  Materials Today Chemistry,  32  (101647).  [PMID:]
7. Chang Liu, Hong Lin, Limin Cao, Kaiqiang Wang, Jianxin Sui.  (2023)  Characterization, specific recognition, and the performance in fish matrix of a shark-derived single-domain antibody against enrofloxacin.  TALANTA,  265  (124852).  [PMID:37385191]
8. Changxing Wang, Feifei Qin, Siyuan Tang, Xiameng Li, Tingting Li, Guoqiang Guo, Chenjie Gu, Xu Wang, Da Chen.  (2023)  Construction of graphene quantum dots ratiometric fluorescent probe by intermolecular electron transfer effect for intelligent and real-time visual detection of ofloxacin and its L-isomer in daily drink.  FOOD CHEMISTRY,  411  (135514).  [PMID:36724609]
9. Rong Shen, Yichang Yu, Qinfang Liu, Ruili Wang, Rong Lan, Hui Feng, Ran Yu, Lihua Jin, Ye Li.  (2022)  Toxic Effects and Mechanism of Pefloxacin on the Early Life Stage of Zebrafish (Danio rerio).  Water,  14  (23): (3857).  [PMID:]
10. Ruizhen Li, Yu Hu, Lijun Du, Jiawen Li, Jigang Yuan, Xingyong Liu.  (2022)  In-situ photoelectrocatalytical formation of sulfate radicals on BiPO4 modified carbon paper electrode in sodium sulfate electrolyte for high efficient degradation of pefloxacin.  JOURNAL OF MOLECULAR STRUCTURE,  1268  (133547).  [PMID:]
11. Lishan Zhang, Zujie Yao, Huamei Tang, Qingli Song, Huanhuan Song, Jindong Yao, Zhen Li, Xiaofang Xie, Yuexu Lin, Xiangmin Lin.  (2022)  The Lysine Acetylation Modification in the Porin Aha1 of Aeromonas hydrophila Regulates the Uptake of Multidrug Antibiotics.  MOLECULAR & CELLULAR PROTEOMICS,  21  (9):   [PMID:35605723]
12. Jin'ai Chen, Yuting Jin, Taotao Ren, Shuo Wang, Xianghong Wang, Fuyuan Zhang, Yiwei Tang.  (2022)  A novel terbium (III) and aptamer-based probe for label-free detection of three fluoroquinolones in honey and water samples.  FOOD CHEMISTRY,  386  (132751).  [PMID:35334319]
13. Huang Hongli, Zheng Yongxin, Wei Dongning, Yang Guang, Peng Xin, Fan Lingjia, Luo Lin, Zhou Yaoyu.  (2022)  Efficient removal of pefloxacin from aqueous solution by acid–alkali modified sludge-based biochar: adsorption kinetics, isotherm, thermodynamics, and mechanism.  ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH,  29  (28): (43201-43211).  [PMID:35091955]
14. Yanzhuo Zhang, Mengqi Xu, Rui He, Jing Zhao, Wei Kang, Jinghua Lv.  (2022)  Effect of pyrolysis temperature on the activated permonosulfate degradation of antibiotics in nitrogen and sulfur-doping biochar: Key role of environmentally persistent free radicals.  CHEMOSPHERE,  294  (133737).  [PMID:35090846]
15. Wenying Fan,Man He,Xiaoran Wu,Beibei Chen,Bin Hu.  (2015-10-05)  Graphene oxide/polyethyleneglycol composite coated stir bar for sorptive extraction of fluoroquinolones from chicken muscle and liver..  Journal of chromatography. A,  1418  (36-44).  [PMID:26433263]

Solution Calculators