Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SKU | Size | Availability | Price | Qty |
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P304448-10mg | 10mg | In stock | $19.90 | |
P304448-25mg | 25mg | In stock | $40.90 | |
P304448-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $135.90 | |
P304448-250mg | 250mg | In stock | $304.90 | |
P304448-1g | 1g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,095.90 |
Synonyms | 1584RB | 1589-RB | Pefloxacin [USAN:INN:BAN] | SBI-0206758.P001 | SMR000273037 | D02306 | Oprea1_063677 | 1-ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid | 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-methylpiperazinyl)quinoline-3- |
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Specifications & Purity | Moligand™, ≥98% |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Topoisomerase IV inhibitor |
ALogP | 0.3 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 1-ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid |
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INCHI | InChI=1S/C17H20FN3O3/c1-3-20-10-12(17(23)24)16(22)11-8-13(18)15(9-14(11)20)21-6-4-19(2)5-7-21/h8-10H,3-7H2,1-2H3,(H,23,24) |
InChi Key | FHFYDNQZQSQIAI-UHFFFAOYSA-N |
Canonical SMILES | CCN1C=C(C(=O)C2=CC(=C(C=C21)N3CCN(CC3)C)F)C(=O)O |
Isomeric SMILES | CCN1C=C(C(=O)C2=CC(=C(C=C21)N3CCN(CC3)C)F)C(=O)O |
PubChem CID | 51081 |
Molecular Weight | 333.36 |
Antibiotic DB | 2039 |
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PubChem CID | 51081 |
ChEMBL Ligand | CHEMBL267648 |
ChEBI | CHEBI:50199 |
DrugBank Ligand | DB00487 |
DrugCentral Ligand | 2071 |
CAS Registry No. | 70458-92-3 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
L2103270 | Certificate of Analysis | Sep 19, 2024 | P304448 |
L2103271 | Certificate of Analysis | Sep 19, 2024 | P304448 |
L2103329 | Certificate of Analysis | Sep 19, 2024 | P304448 |
L2103330 | Certificate of Analysis | Sep 19, 2024 | P304448 |
L2304031 | Certificate of Analysis | Nov 08, 2021 | P304448 |
Pictogram(s) | GHS07 |
---|---|
Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
1. Yanzhuo Zhang, Yutai Sun, Rui He, Jing Zhao, Jiqin Wang, Tonghuan Yu, Xiaozhuan Zhang, Alexandr V. Bildyukevich. (2024) Effects of excess sludge composting process, environmentally persistent free radicals, and microplastics on antibiotics degradation efficiency of aging biochar. BIORESOURCE TECHNOLOGY, 393 (15): (130070). [PMID:37984667] [10.1016/j.biortech.2023.130070] |
2. Xuan Wan, Haohao Du, Du Tuo, Xiaoman Qi, Tianyu Wang, Jingtao Wu, Guangli Li. (2023) UiO-66/Carboxylated Multiwalled Carbon Nanotube Composites for Highly Efficient and Stable Voltammetric Sensors for Gatifloxacin. ACS Applied Nano Materials, 6 (20): (19403–19413). [PMID:15378032] [10.1021/acsanm.3c03874] |
3. Guangli Li, Xuan Wan, Yonghui Xia, Du Tuo, Xiaoman Qi, Tianyu Wang, Mohammad Mehmandoust, Nevin Erk, Quanguo He, Qing Li. (2023) Lamellar α-Zirconium Phosphate Nanoparticles Supported on N-Doped Graphene Nanosheets as Electrocatalysts for the Detection of Levofloxacin. ACS Applied Nano Materials, 6 (18): (17040–17052). [PMID:11485546] [10.1021/acsanm.3c03162] |
4. Han Yin, Ziyi Zhen, Weijie Ning, Lu Zhang, Yuhong Xiang, Nengsheng Ye. (2023) Three-dimensional fluorinated covalent organic frameworks coated capillary for the separation of fluoroquinolones by capillary electrochromatography. JOURNAL OF CHROMATOGRAPHY A, 1706 (464234). [PMID:37523908] [10.1016/j.chroma.2023.464234] |
5. L. Wang, D. Wang, Y. Tao, J. Wang, M. Tian, Q. Liu, Y. Yang, Y. Zou, F. Ke, X. Guo, X. Li, D. Gao. (2023) Phenylboronic acid functionalized high-crystallinity fluorescent covalent organic framework act as a sensing platform with dual performance for rifamycin antibiotics and water and adsorbent for rifamycin antibiotics. Materials Today Chemistry, 32 (101647). [PMID:] [10.1016/j.mtchem.2023.101647] |
6. Chang Liu, Hong Lin, Limin Cao, Kaiqiang Wang, Jianxin Sui. (2023) Characterization, specific recognition, and the performance in fish matrix of a shark-derived single-domain antibody against enrofloxacin. TALANTA, 265 (124852). [PMID:37385191] [10.1016/j.talanta.2023.124852] |
7. Changxing Wang, Feifei Qin, Siyuan Tang, Xiameng Li, Tingting Li, Guoqiang Guo, Chenjie Gu, Xu Wang, Da Chen. (2023) Construction of graphene quantum dots ratiometric fluorescent probe by intermolecular electron transfer effect for intelligent and real-time visual detection of ofloxacin and its L-isomer in daily drink. FOOD CHEMISTRY, 411 (135514). [PMID:36724609] [10.1016/j.foodchem.2023.135514] |
8. Rong Shen, Yichang Yu, Qinfang Liu, Ruili Wang, Rong Lan, Hui Feng, Ran Yu, Lihua Jin, Ye Li. (2022) Toxic Effects and Mechanism of Pefloxacin on the Early Life Stage of Zebrafish (Danio rerio). Water, 14 (23): (3857). [PMID:] [10.3390/w14233857] |
9. Ruizhen Li, Yu Hu, Lijun Du, Jiawen Li, Jigang Yuan, Xingyong Liu. (2022) In-situ photoelectrocatalytical formation of sulfate radicals on BiPO4 modified carbon paper electrode in sodium sulfate electrolyte for high efficient degradation of pefloxacin. JOURNAL OF MOLECULAR STRUCTURE, 1268 (133547). [PMID:] [10.1016/j.molstruc.2022.133547] |
10. Lishan Zhang, Zujie Yao, Huamei Tang, Qingli Song, Huanhuan Song, Jindong Yao, Zhen Li, Xiaofang Xie, Yuexu Lin, Xiangmin Lin. (2022) The Lysine Acetylation Modification in the Porin Aha1 of Aeromonas hydrophila Regulates the Uptake of Multidrug Antibiotics. MOLECULAR & CELLULAR PROTEOMICS, 21 (9): [PMID:35605723] [10.1016/j.mcpro.2022.100248] |
11. Jin'ai Chen, Yuting Jin, Taotao Ren, Shuo Wang, Xianghong Wang, Fuyuan Zhang, Yiwei Tang. (2022) A novel terbium (III) and aptamer-based probe for label-free detection of three fluoroquinolones in honey and water samples. FOOD CHEMISTRY, 386 (132751). [PMID:35334319] [10.1016/j.foodchem.2022.132751] |
12. Huang Hongli, Zheng Yongxin, Wei Dongning, Yang Guang, Peng Xin, Fan Lingjia, Luo Lin, Zhou Yaoyu. (2022) Efficient removal of pefloxacin from aqueous solution by acid–alkali modified sludge-based biochar: adsorption kinetics, isotherm, thermodynamics, and mechanism. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 29 (28): (43201-43211). [PMID:35091955] [10.1007/s11356-021-18220-9] |
13. Yanzhuo Zhang, Mengqi Xu, Rui He, Jing Zhao, Wei Kang, Jinghua Lv. (2022) Effect of pyrolysis temperature on the activated permonosulfate degradation of antibiotics in nitrogen and sulfur-doping biochar: Key role of environmentally persistent free radicals. CHEMOSPHERE, 294 (133737). [PMID:35090846] [10.1016/j.chemosphere.2022.133737] |
14. Yu Wang, Jin-Yi Yang, Ying He, Lu Li, Jian-Xin Huang, Yuan-Xin Tian, Hong Wang, Zhen-Lin Xu, Yu-Dong Shen. (2021) Development of Time-Resolved Fluorescence Immunochromatographic Assays for Simultaneously Detecting Tylosin and Tilmicosin in Milk in Group-Screening Manner. Foods, 10 (8): (1838). [PMID:34441616] [10.3390/foods10081838] |
15. Yukun Huang, Chong Wang, Qiming Wei, Yaning Song, Pengfei Chen, Lijun Wang, Xiao Yang, Xianggui Chen. (2021) A sensitive aptasensor based on rolling circle amplification and G-rich ssDNA/terbium (III) luminescence enhancement for ofloxacin detection in food. TALANTA, 235 (122783). [PMID:34517641] [10.1016/j.talanta.2021.122783] |
16. Cuizhu Ye, Xingguang Chen, Dong Zhang, Junjun Xu, Huiting Xi, Tiantian Wu, Danwen Deng, Chunhong Xiong, Jinsheng Zhang, Ganhui Huang. (2021) Study on the properties and reaction mechanism of polypyrrole@norfloxacin molecularly imprinted electrochemical sensor based on three-dimensional CoFe-MOFs/AuNPs. ELECTROCHIMICA ACTA, 379 (138174). [PMID:] [10.1016/j.electacta.2021.138174] |
17. Xiangning Han, Hong Lin, Limin Cao, Xiangfeng Chen, Luefeng Wang, Hongwei Zheng, Ziang Zhang, Tushar Ramesh Pavase, Sai Wang, Xun Sun, Jianxin Sui. (2020) Hapten-Branched Polyethylenimine as a New Antigen Affinity Ligand to Purify Antibodies with High Efficiency and Specificity. ACS Applied Materials & Interfaces, 12 (52): (58191–58200). [PMID:33319977] [10.1021/acsami.0c15586] |
18. Chun Yang, Rui Li, Qi Wang, Wenhao Wang, Pei Gao, Bibo Hu. (2021) Synthesis of alkyl-functionalized magnetic for fluoroquinolones removal: Adsorption performance and mechanism studies in single and binary systems. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 608 (125549). [PMID:] [10.1016/j.colsurfa.2020.125549] |
19. Zhenping Liu, Mingliang Jin, Han Lu, Jiyuan Yao, Xin Wang, Guofu Zhou, Lingling Shui. (2019) Molecularly imprinted polymer decorated 3D-framework of functionalized multi-walled carbon nanotubes for ultrasensitive electrochemical sensing of Norfloxacin in pharmaceutical formulations and rat plasma. SENSORS AND ACTUATORS B-CHEMICAL, 288 (363). [PMID:] [10.1016/j.snb.2019.02.097] |
20. Hua Jianhao, Jiao Yang, Wang Meng, Yang Yaling. (2018) Determination of norfloxacin or ciprofloxacin by carbon dots fluorescence enhancement using magnetic nanoparticles as adsorbent. MICROCHIMICA ACTA, 185 (2): (1-9). [PMID:29594473] [10.1007/s00604-018-2685-x] |
21. Dan Liu, Jiutong Ma, Yan Jin, Xiqian Li, Xiao Zhou, Qiong Jia, Weihong Zhou. (2014) Preparation of a monolith functionalized with zinc oxide nanoparticles and its application in the enrichment of fluoroquinolone antibiotics. JOURNAL OF SEPARATION SCIENCE, 38 (1): (134-140). [PMID:25354394] [10.1002/jssc.201400893] |
22. Wenying Fan,Man He,Xiaoran Wu,Beibei Chen,Bin Hu. (2015-10-05) Graphene oxide/polyethyleneglycol composite coated stir bar for sorptive extraction of fluoroquinolones from chicken muscle and liver.. Journal of chromatography. A, 1418 (36-44). [PMID:26433263] |
1. Yourassowsky E, Van der Linden MP, Crokaert F, Glupczynski Y. (1986) In-vitro activity of pefloxacin compared to other antibiotics.. J Antimicrob Chemother, 17 Suppl B (13): (19-28). [PMID:3086279] [10.1021/op500134e] |
2. Yanzhuo Zhang, Yutai Sun, Rui He, Jing Zhao, Jiqin Wang, Tonghuan Yu, Xiaozhuan Zhang, Alexandr V. Bildyukevich. (2024) Effects of excess sludge composting process, environmentally persistent free radicals, and microplastics on antibiotics degradation efficiency of aging biochar. BIORESOURCE TECHNOLOGY, 393 (15): (130070). [PMID:37984667] [10.1016/j.biortech.2023.130070] |
3. Xuan Wan, Haohao Du, Du Tuo, Xiaoman Qi, Tianyu Wang, Jingtao Wu, Guangli Li. (2023) UiO-66/Carboxylated Multiwalled Carbon Nanotube Composites for Highly Efficient and Stable Voltammetric Sensors for Gatifloxacin. ACS Applied Nano Materials, 6 (20): (19403–19413). [PMID:15378032] [10.1021/acsanm.3c03874] |
4. Guangli Li, Xuan Wan, Yonghui Xia, Du Tuo, Xiaoman Qi, Tianyu Wang, Mohammad Mehmandoust, Nevin Erk, Quanguo He, Qing Li. (2023) Lamellar α-Zirconium Phosphate Nanoparticles Supported on N-Doped Graphene Nanosheets as Electrocatalysts for the Detection of Levofloxacin. ACS Applied Nano Materials, 6 (18): (17040–17052). [PMID:11485546] [10.1021/acsanm.3c03162] |
5. Han Yin, Ziyi Zhen, Weijie Ning, Lu Zhang, Yuhong Xiang, Nengsheng Ye. (2023) Three-dimensional fluorinated covalent organic frameworks coated capillary for the separation of fluoroquinolones by capillary electrochromatography. JOURNAL OF CHROMATOGRAPHY A, 1706 (464234). [PMID:37523908] [10.1016/j.chroma.2023.464234] |
6. L. Wang, D. Wang, Y. Tao, J. Wang, M. Tian, Q. Liu, Y. Yang, Y. Zou, F. Ke, X. Guo, X. Li, D. Gao. (2023) Phenylboronic acid functionalized high-crystallinity fluorescent covalent organic framework act as a sensing platform with dual performance for rifamycin antibiotics and water and adsorbent for rifamycin antibiotics. Materials Today Chemistry, 32 (101647). [PMID:] [10.1016/j.mtchem.2023.101647] |
7. Chang Liu, Hong Lin, Limin Cao, Kaiqiang Wang, Jianxin Sui. (2023) Characterization, specific recognition, and the performance in fish matrix of a shark-derived single-domain antibody against enrofloxacin. TALANTA, 265 (124852). [PMID:37385191] [10.1016/j.talanta.2023.124852] |
8. Changxing Wang, Feifei Qin, Siyuan Tang, Xiameng Li, Tingting Li, Guoqiang Guo, Chenjie Gu, Xu Wang, Da Chen. (2023) Construction of graphene quantum dots ratiometric fluorescent probe by intermolecular electron transfer effect for intelligent and real-time visual detection of ofloxacin and its L-isomer in daily drink. FOOD CHEMISTRY, 411 (135514). [PMID:36724609] [10.1016/j.foodchem.2023.135514] |
9. Rong Shen, Yichang Yu, Qinfang Liu, Ruili Wang, Rong Lan, Hui Feng, Ran Yu, Lihua Jin, Ye Li. (2022) Toxic Effects and Mechanism of Pefloxacin on the Early Life Stage of Zebrafish (Danio rerio). Water, 14 (23): (3857). [PMID:] [10.3390/w14233857] |
10. Ruizhen Li, Yu Hu, Lijun Du, Jiawen Li, Jigang Yuan, Xingyong Liu. (2022) In-situ photoelectrocatalytical formation of sulfate radicals on BiPO4 modified carbon paper electrode in sodium sulfate electrolyte for high efficient degradation of pefloxacin. JOURNAL OF MOLECULAR STRUCTURE, 1268 (133547). [PMID:] [10.1016/j.molstruc.2022.133547] |
11. Lishan Zhang, Zujie Yao, Huamei Tang, Qingli Song, Huanhuan Song, Jindong Yao, Zhen Li, Xiaofang Xie, Yuexu Lin, Xiangmin Lin. (2022) The Lysine Acetylation Modification in the Porin Aha1 of Aeromonas hydrophila Regulates the Uptake of Multidrug Antibiotics. MOLECULAR & CELLULAR PROTEOMICS, 21 (9): [PMID:35605723] [10.1016/j.mcpro.2022.100248] |
12. Jin'ai Chen, Yuting Jin, Taotao Ren, Shuo Wang, Xianghong Wang, Fuyuan Zhang, Yiwei Tang. (2022) A novel terbium (III) and aptamer-based probe for label-free detection of three fluoroquinolones in honey and water samples. FOOD CHEMISTRY, 386 (132751). [PMID:35334319] [10.1016/j.foodchem.2022.132751] |
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