Pelitinib - ≥98%, high purity , Epidermal growth factor receptor erbB1 inhibitor, CAS No.257933-82-7, Epidermal growth factor receptor erbB1 inhibitor

Item Number

P125444

• Synonyms: EKB-569 | Glyoxylic acid, 2-(dimethyl acetal) | (E)-N-(4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide | X5DWL380Z6 | UNII-X5DWL380Z6 | 1-(2-hydroxy-4,6-dimethoxy-phenyl)ethanone | 4-chloro-2-amino-benzoic ac
• Specifications & Purity: Moligand™, ≥98%
• Biochemical and Physiological Mechanisms: Pelitinib is a tyrosine kinase inhibitor that covalently binds to EGFR, inhibiting receptor phosphorylation and thus inhibiting signal transduction from EGFR. This induces apoptosis and thus leads to suppression of growth in tumor cell lines.Irreversible
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: INHIBITOR
• Mechanism of action: Epidermal growth factor receptor erbB1 inhibitor
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

Pelitinib (EKB-569) is a potent irreversible EGFR inhibitor with IC50 of 38.5 nM.
An EGFR inhibitor