Pembrolizumab (anti-PD-1), for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to PDCD1, >95%, high purity, Human IgG4SP, Antibody of programmed cell death 1 (CD279)

Features and benefits
  • Short Overview:

    Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG4SP; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

  • Application: ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR)
  • Species reactivity(Reacts with): Cynomolgus monkey,Human
  • Isotype: Human IgG4SP
    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
Item Number
P411997
Grouped product items
SKUSizeAvailabilityPrice Qty
P411997-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$39.90
P411997-1mg
1mg
In stock
$159.90
P411997-5mg
5mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$664.90
P411997-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,196.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG4SP; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product NamePembrolizumab (anti-PD-1), for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to PDCD1, >95%, high purity, Human IgG4SP
Synonyms1374853-91-4 | 1-butyl-4-propylpiperazine;ethane;1-[hex-5-enyl(2-methyltetradecyl)amino]tetradecan-2-ol;3-[[(8E,10E)-2-methylhexadeca-8,10-dienyl]-[(9E,11E)-2-methylhexadeca-9,11-dienyl]amino]propane-1-thiol
Specifications & PurityExactAb™, Validated, Carrier Free, Low Endotoxin, Azide Free, Recombinant, ≥95%(SDS-PAGE&SEC), Lot by Lot
SpecificityPDCD1
ApplicationELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR)
ConjugationUnconjugated
GradeAzide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action TypeINHIBITOR
Mechanism of actionAntibody of programmed cell death 1 (CD279)
Product Description

Pembrolizumab (anti-PD-1) is a potent, highly selective, fully humanized immunoglobulin (Ig) G4-kappa monoclonal antibody against PD-1 with potential immune checkpoint inhibitory and antineoplastic activities.
Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg 

Product Properties

Antibody TypePrimary antibody
ClonalityRecombinant
IsotypeHuman IgG4SP
SDS-PAGE146 kDa
Purification MethodProtein A purified
Purity>95%
SourceCHO supernatant
FormLiquid
ConcentrationLot by Lot
Storage TempStore at -80°C,Avoid repeated freezing and thawing
Shipped InIce chest + Ice pads
Stability And StorageStore at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
CAS1374853-91-4

Images

Pembrolizumab (anti-PD-1) (P411997) - Flow Cytometry
Flow Cytometry analysis of PHA-stimulated (3 days) human peripheral blood mononuclear lymphocytes labelling PD-1 (red) with Pembrolizumab (anti-PD-1) (P411997). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Pembrolizumab (anti-PD-1) (P411997) - SEC
The purity of Pembrolizumab (anti-PD-1) (P411997) is more than 95% verified by HPLC.

Associated Targets(Human)

PDCD1 Tclin Programmed cell death protein 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PDCD1 Tclin Programmed cell death protein 1 (14 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PDCD1 Tclin Programmed cell death protein 1/Programmed cell death 1 ligand 1 (1367 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot NumberCertificate TypeDateItem
ZJ24F0707872Certificate of AnalysisJul 05, 2024 P411997
ZJ23F0900991Certificate of AnalysisSep 11, 2023 P411997
ZJ23F0900990Certificate of AnalysisSep 11, 2023 P411997

Related Documents

References

1. Janakiram M, Abadi YM, Sparano JA, Zang X.  (2012)  T cell coinhibition and immunotherapy in human breast cancer..  Discov Med,  14  (77): (229-36).  [PMID:23114578]
2. Greaves P, Gribben JG.  (2013)  The role of B7 family molecules in hematologic malignancy..  Blood,  121  (5): (734-44).  [PMID:23223433]
3. Tang PA, Heng DY.  (2013)  Programmed death 1 pathway inhibition in metastatic renal cell cancer and prostate cancer..  Curr Oncol Rep,  15  (2): (98-104).  [PMID:23263823]
4. Hamid O, Robert C, Daud A, Hodi FS, Hwu WJ, Kefford R, Wolchok JD, Hersey P, Joseph RW, Weber JS et al..  (2013)  Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma..  N Engl J Med,  369  (2): (134-44).  [PMID:23724846]
5. Nghiem PT, Bhatia S, Lipson EJ, Kudchadkar RR, Miller NJ, Annamalai L, Berry S, Chartash EK, Daud A, Fling SP et al..  (2016)  PD-1 Blockade with Pembrolizumab in Advanced Merkel-Cell Carcinoma..  N Engl J Med,  374  (26): (2542-52).  [PMID:27093365]
6. Paz-Ares L, Luft A, Vicente D, Tafreshi A, Gümüş M, Mazières J, Hermes B, Çay Şenler F, Csőszi T, Fülöp A et al..  (2018)  Pembrolizumab plus Chemotherapy for Squamous Non-Small-Cell Lung Cancer..  N Engl J Med,  379  (21): (2040-2051).  [PMID:30280635]
7. Rini BI, Plimack ER, Stus V, Gafanov R, Hawkins R, Nosov D, Pouliot F, Alekseev B, Soulières D, Melichar B et al..  (2019)  Pembrolizumab plus Axitinib versus Sunitinib for Advanced Renal-Cell Carcinoma..  N Engl J Med,  380  (12): (1116-1127).  [PMID:30779529]
8. Saada-Bouzid E, Peyrade F, Guigay J.  (2019)  Immunotherapy in recurrent and or metastatic squamous cell carcinoma of the head and neck..  Curr Opin Oncol,  31  (3): (146-151).  [PMID:30893146]

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