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Pemigatinib - ≥98%, high purity , Fibroblast growth factor receptor 1 inhibitor, CAS No.1513857-77-6, Fibroblast growth factor receptor 1 inhibitor
Basic Description
| Synonyms | Pemigatinib|1513857-77-6|Pemazyre|INCB054828|Fgfr inhibitor INCB054828|Y6BX7BL23K|Pemigatinib [INN]|Pemigatinib [USAN]|INCB54828|INCB-54828|INCB-054828|UNII-Y6BX7BL23K|INCB 54828|1513857-77-6 (free base)|2H-Pyrrolo(3',2':5,6)pyrido(4,3-d)pyrimidin-2-one, |
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| Specifications & Purity | Moligand™, ≥98% |
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| Storage Temp | Store at -20°C |
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| Shipped In | Ice chest + Ice pads |
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| Grade | Moligand™ |
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| Action Type | INHIBITOR |
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| Mechanism of action | Fibroblast growth factor receptor 1 inhibitor |
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Names and Identifiers
| IUPAC Name | 11-(2,6-difluoro-3,5-dimethoxyphenyl)-13-ethyl-4-(morpholin-4-ylmethyl)-5,7,11,13-tetrazatricyclo[7.4.0.02,6]trideca-1,3,6,8-tetraen-12-one |
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| INCHI | InChI=1S/C24H27F2N5O4/c1-4-30-21-14(11-27-23-16(21)9-15(28-23)13-29-5-7-35-8-6-29)12-31(24(30)32)22-19(25)17(33-2)10-18(34-3)20(22)26/h9-11H,4-8,12-13H2,1-3H3,(H,27,28) |
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| InChi Key | HCDMJFOHIXMBOV-UHFFFAOYSA-N |
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| Canonical SMILES | CCN1C2=C3C=C(NC3=NC=C2CN(C1=O)C4=C(C(=CC(=C4F)OC)OC)F)CN5CCOCC5 |
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| Isomeric SMILES | CCN1C2=C3C=C(NC3=NC=C2CN(C1=O)C4=C(C(=CC(=C4F)OC)OC)F)CN5CCOCC5 |
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| PubChem CID | 86705695 |
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| Molecular Weight | 487.50 |
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Safety and Hazards(GHS)
| Pictogram(s) | GHS07 |
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| Signal | Warning |
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| Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed |
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| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. |
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References
| 1. Chan CL, Jones RL, Lau HY. (2020) Pemigatinib Is Active in Some FGFR2-Altered Cholangiocarcinomas.. Cancer Discov, 10 (5): (639). [PMID:32245820] |
| 2. Romero D. (2020) Benefit from pemigatinib in cholangiocarcinoma.. Nat Rev Clin Oncol, 17 (6): (337). [PMID:32300194] |
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