Grouped product items

SKU

Size

Availability

Price

Qty

P288316-50mg

50mg

In stock

$28.90

P288316-250mg

250mg

In stock

$130.90

P288316-1g

In stock

$469.90

P288316-5g

In stock

$2,114.90

Basic Description

Synonyms	PENTAMIDINE ISETHIONATE\|140-64-7\|Pentamidine isethionate salt\|Pentamidine diisethionate\|4,4'-(Pentane-1,5-diylbis(oxy))dibenzimidamide bis(2-hydroxyethanesulfonate)\|Pentamidine isetionate\|Pentacarinat\|Nebupent\|Pentamidine diisetionate\|Lomidin\|Pneumopent\|P
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Antimicrobial. Neuroprotective; inhibits constitutive nitric oxide synthase in the brain and acts as a NMDA glutamate receptor antagonist.Neuroprotective; inhibits constitutive nitric oxide synthase in the brain; NMDA glutamate receptor antagonist. Pentam
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Action Type	INHIBITOR
Mechanism of action	Kinetoplast DNA inhibitor
Product Description	Product Describtion: Pentamidine isethionate salt has been used: as a positive control for anti-leishmanial, anti-plasmodial and cytotoxic assays as a prototypical compound to analyse the inhibitor effect on human ether-a-go-go-related gene (HERG) K+ channel trafficking as an anti-leishmanial agent in promastigotes Antimicrobial against Pneumocystis carinii.

Associated Targets

CYP1A2 Tchem Cytochrome P450 1A2 0 Activities

Discover Target: CYP1A2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2D6 Tclin Cytochrome P450 2D6 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2C19 Tchem Cytochrome P450 2C19 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

Discover Target: CYP3A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

POLB Tchem DNA polymerase beta 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

EHMT2 Tchem Histone-lysine N-methyltransferase EHMT2 0 Activities

Discover Target: EHMT2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2C9 Tchem Cytochrome P450 2C9 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GMNN Tbio Geminin 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

POLH Tchem DNA polymerase eta 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HIF1A Tchem Hypoxia-inducible factor 1-alpha 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FEN1 Tchem Flap endonuclease 1 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

THPO Tbio Thrombopoietin 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SMN1 Tchem Survival motor neuron protein 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

POLK Tbio DNA polymerase kappa 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

POLI Tchem DNA polymerase iota 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RAB9A Tbio Ras-related protein Rab-9A 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PMP22 Tbio Peripheral myelin protein 22 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RECQL Tbio ATP-dependent DNA helicase Q1 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PKM Tchem Pyruvate kinase PKM 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

LMNA Tbio Prelamin-A/C 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ALOX15B Tchem Arachidonate 15-lipoxygenase B 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BLM Tchem Bloom syndrome protein 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 0 Activities

Discover Target: TDP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHRM1 Tclin Muscarinic acetylcholine receptor M1 0 Activities

Discover Target: CHRM1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ALDH1A1 Tchem Retinal dehydrogenase 1 0 Activities

Discover Target: ALDH1A1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ATAD5 Tbio ATPase family AAA domain-containing protein 5 0 Activities

Discover Target: ATAD5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KDM4E Tchem Lysine-specific demethylase 4E 0 Activities

Discover Target: KDM4E

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MTOR Tclin Serine/threonine-protein kinase mTOR 0 Activities

Discover Target: MTOR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	4-[5-(4-carbamimidoylphenoxy)pentoxy]benzenecarboximidamide;2-hydroxyethanesulfonic acid
INCHI	InChI=1S/C19H24N4O2.2C2H6O4S/c20-18(21)14-4-8-16(9-5-14)24-12-2-1-3-13-25-17-10-6-15(7-11-17)19(22)23;23-1-2-7(4,5)6/h4-11H,1-3,12-13H2,(H3,20,21)(H3,22,23);23H,1-2H2,(H,4,5,6)
InChi Key	YBVNFKZSMZGRAD-UHFFFAOYSA-N
Canonical SMILES	C1=CC(=CC=C1C(=N)N)OCCCCCOC2=CC=C(C=C2)C(=N)N.C(CS(=O)(=O)O)O.C(CS(=O)(=O)O)O
Isomeric SMILES	C1=CC(=CC=C1C(=N)N)OCCCCCOC2=CC=C(C=C2)C(=N)N.C(CS(=O)(=O)O)O.C(CS(=O)(=O)O)O
PubChem CID	8813
Molecular Weight	592.68

Certificates

Certificate of Analysis(COA)

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4 results found

Lot Number	Certificate Type	Date	Item
A2212351	Certificate of Analysis	Dec 21, 2021	P288316
A2212357	Certificate of Analysis	Dec 21, 2021	P288316
A2212479	Certificate of Analysis	Dec 21, 2021	P288316
A2212480	Certificate of Analysis	Dec 21, 2021	P288316

Chemical and Physical Properties

Solubility	Solvent:water, Max Conc. mg/mL: 59.27, Max Conc. mM: 100
Sensitivity	Light sensitive

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H317:May cause an allergic skin reaction
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.

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Pentamidine isethionate - ≥98%, high purity , Kinetoplast DNA inhibitor, CAS No.140-64-7, Kinetoplast DNA inhibitor

Basic Description

Associated Targets

CYP1A2 Tchem Cytochrome P450 1A2 0 Activities

CYP2D6 Tclin Cytochrome P450 2D6 0 Activities

CYP2C19 Tchem Cytochrome P450 2C19 0 Activities

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

POLB Tchem DNA polymerase beta 0 Activities

EHMT2 Tchem Histone-lysine N-methyltransferase EHMT2 0 Activities

CYP2C9 Tchem Cytochrome P450 2C9 0 Activities

GMNN Tbio Geminin 0 Activities

POLH Tchem DNA polymerase eta 0 Activities

HIF1A Tchem Hypoxia-inducible factor 1-alpha 0 Activities

FEN1 Tchem Flap endonuclease 1 0 Activities

THPO Tbio Thrombopoietin 0 Activities

SMN1 Tchem Survival motor neuron protein 0 Activities

POLK Tbio DNA polymerase kappa 0 Activities

POLI Tchem DNA polymerase iota 0 Activities

RAB9A Tbio Ras-related protein Rab-9A 0 Activities

PMP22 Tbio Peripheral myelin protein 22 0 Activities

RECQL Tbio ATP-dependent DNA helicase Q1 0 Activities

PKM Tchem Pyruvate kinase PKM 0 Activities

LMNA Tbio Prelamin-A/C 0 Activities

ALOX15B Tchem Arachidonate 15-lipoxygenase B 0 Activities

BLM Tchem Bloom syndrome protein 0 Activities

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 0 Activities

CHRM1 Tclin Muscarinic acetylcholine receptor M1 0 Activities

ALDH1A1 Tchem Retinal dehydrogenase 1 0 Activities

ATAD5 Tbio ATPase family AAA domain-containing protein 5 0 Activities

KDM4E Tchem Lysine-specific demethylase 4E 0 Activities

MTOR Tclin Serine/threonine-protein kinase mTOR 0 Activities

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

Solution Calculators

Molarity Calculator

Dilution Calculator

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