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Pentoxifylline - >98.0%, high purity , Adenosine A2 receptor antagonist, CAS No.6493-05-6, Adenosine A2 receptor antagonist

Specifications & Purity:  >98.0%
Item Number
P160702
Grouped product items
SKUSizeAvailabilityPrice Qty
P160702-1g
1g
In stock
$58.90
P160702-5g
5g
In stock
$265.90
P160702-25g
25g
In stock
$1,194.90
P160702-100g
100g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$4,301.90

Phosphodiesterase inhibitor. Cytokine inhibitor.

View related series
A2B receptor Antagonist

Basic Description

Synonymspentoxifylline|Trental|6493-05-6|Oxpentifylline|Pentoxifyllin|Pentoxyphylline|Torental|Pentoxiphyllium|Vazofirin|Dimethyloxohexylxanthine|3,7-Dimethyl-1-(5-oxohexyl)xanthine|Pentoxiphyllin|Pentoxiphylline|Pentoxyfylline|1-(5-Oxohexyl)theobromine|Rentylin|
Specifications & Purity>98.0%
Storage TempStore at -20°C
Shipped InDry ice
Action TypeANTAGONIST
Mechanism of actionAdenosine A2 receptor antagonist

Product Properties

ALogP0.3

Associated Targets

ADORA2B Tclin Adenosine receptor A2b 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 3,7-dimethyl-1-(5-oxohexyl)purine-2,6-dione
INCHI InChI=1S/C13H18N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13(17)20/h8H,4-7H2,1-3H3
InChi Key BYPFEZZEUUWMEJ-UHFFFAOYSA-N
Canonical SMILES CC(=O)CCCCN1C(=O)C2=C(N=CN2C)N(C1=O)C
Isomeric SMILES CC(=O)CCCCN1C(=O)C2=C(N=CN2C)N(C1=O)C
RTECS XH2475000
PubChem CID 4740
Molecular Weight 278.31
Reaxy-Rn 558929

Certificates

Certificate of Analysis(COA)

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7 results found

Lot NumberCertificate TypeDateItem
K2211694Certificate of AnalysisSep 28, 2022 P160702
K2211758Certificate of AnalysisSep 28, 2022 P160702
K2211760Certificate of AnalysisSep 28, 2022 P160702
K2211786Certificate of AnalysisSep 28, 2022 P160702
G2207364Certificate of AnalysisJun 10, 2022 P160702
G2207365Certificate of AnalysisJun 10, 2022 P160702
G2207366Certificate of AnalysisJun 10, 2022 P160702

Chemical and Physical Properties

Melt Point(°C)105 °C

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements H302
Precautionary Statements P501,P264,P270,P330,P301+P317
RTECS XH2475000
Reaxy-Rn 558929
Merck Index 7136

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References

1. Essayan DM.  (2001)  Cyclic nucleotide phosphodiesterases..  J Allergy Clin Immunol,  108  (5): (671-80).  [PMID:11692087]
2. Trevethick MA, Mantell SJ, Stuart EF, Barnard A, Wright KN, Yeadon M.  (2008)  Treating lung inflammation with agonists of the adenosine A2A receptor: promises, problems and potential solutions..  Br J Pharmacol,  155  (4): (463-74).  [PMID:18846036]
3. Konrad FM, Neudeck G, Vollmer I, Ngamsri KC, Thiel M, Reutershan J.  (2013)  Protective effects of pentoxifylline in pulmonary inflammation are adenosine receptor A2A dependent..  FASEB J,  27  (9): (3524-35).  [PMID:23699177]
4. Ward A, Clissold SP.  (1987)  Pentoxifylline. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic efficacy..  Drugs,  34  (1): (50-97).  [PMID:3308412]
5. Basnet RM et al..  (2017)  Methylxanthines induce structural and functional alterations of the cardiac system in zebrafish embryos..  BMC Pharmacol Toxicol,  18  (72).  [PMID:29141695]
6. Basnet RM et al..  (2017)  Zebrafish Embryo as an In Vivo Model for Behavioral and Pharmacological Characterization of Methylxanthine Drugs..  Int J Mol Sci,  18  (3):   [PMID:28282918]

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