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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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P160702-1g | 1g | In stock | $58.90 | |
P160702-5g | 5g | In stock | $265.90 | |
P160702-25g | 25g | In stock | $1,194.90 | |
P160702-100g | 100g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $4,301.90 |
Phosphodiesterase inhibitor. Cytokine inhibitor.
Synonyms | pentoxifylline|Trental|6493-05-6|Oxpentifylline|Pentoxifyllin|Pentoxyphylline|Torental|Pentoxiphyllium|Vazofirin|Dimethyloxohexylxanthine|3,7-Dimethyl-1-(5-oxohexyl)xanthine|Pentoxiphyllin|Pentoxiphylline|Pentoxyfylline|1-(5-Oxohexyl)theobromine|Rentylin| |
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Specifications & Purity | >98.0% |
Storage Temp | Store at -20°C |
Shipped In | Dry ice |
Action Type | ANTAGONIST |
Mechanism of action | Adenosine A2 receptor antagonist |
ALogP | 0.3 |
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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IUPAC Name | 3,7-dimethyl-1-(5-oxohexyl)purine-2,6-dione |
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INCHI | InChI=1S/C13H18N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13(17)20/h8H,4-7H2,1-3H3 |
InChi Key | BYPFEZZEUUWMEJ-UHFFFAOYSA-N |
Canonical SMILES | CC(=O)CCCCN1C(=O)C2=C(N=CN2C)N(C1=O)C |
Isomeric SMILES | CC(=O)CCCCN1C(=O)C2=C(N=CN2C)N(C1=O)C |
RTECS | XH2475000 |
PubChem CID | 4740 |
Molecular Weight | 278.31 |
Reaxy-Rn | 558929 |
DrugBank Ligand | DB00806 |
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PubChem CID | 4740 |
CAS Registry No. | 6493-05-6 |
ChEMBL Ligand | CHEMBL628 |
Wikipedia | Pentoxifylline |
RCSB PDB Ligand | PNX |
PEP | pentoxifylline |
DrugCentral Ligand | 2099 |
GPCRdb Ligand | pentoxifylline |
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Lot Number | Certificate Type | Date | Item |
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Certificate of Analysis | Sep 28, 2022 | P160702 | |
Certificate of Analysis | Sep 28, 2022 | P160702 | |
Certificate of Analysis | Sep 28, 2022 | P160702 | |
Certificate of Analysis | Sep 28, 2022 | P160702 | |
Certificate of Analysis | Jun 10, 2022 | P160702 | |
Certificate of Analysis | Jun 10, 2022 | P160702 | |
Certificate of Analysis | Jun 10, 2022 | P160702 |
Melt Point(°C) | 105 °C |
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Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H302 |
Precautionary Statements | P501,P264,P270,P330,P301+P317 |
RTECS | XH2475000 |
Reaxy-Rn | 558929 |
Merck Index | 7136 |
Starting at $1,716.90
Starting at $332.90
Starting at $69.90
1. Essayan DM. (2001) Cyclic nucleotide phosphodiesterases.. J Allergy Clin Immunol, 108 (5): (671-80). [PMID:11692087] |
2. Trevethick MA, Mantell SJ, Stuart EF, Barnard A, Wright KN, Yeadon M. (2008) Treating lung inflammation with agonists of the adenosine A2A receptor: promises, problems and potential solutions.. Br J Pharmacol, 155 (4): (463-74). [PMID:18846036] |
3. Konrad FM, Neudeck G, Vollmer I, Ngamsri KC, Thiel M, Reutershan J. (2013) Protective effects of pentoxifylline in pulmonary inflammation are adenosine receptor A2A dependent.. FASEB J, 27 (9): (3524-35). [PMID:23699177] |
4. Ward A, Clissold SP. (1987) Pentoxifylline. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic efficacy.. Drugs, 34 (1): (50-97). [PMID:3308412] |
5. Basnet RM et al.. (2017) Methylxanthines induce structural and functional alterations of the cardiac system in zebrafish embryos.. BMC Pharmacol Toxicol, 18 (72). [PMID:29141695] |
6. Basnet RM et al.. (2017) Zebrafish Embryo as an In Vivo Model for Behavioral and Pharmacological Characterization of Methylxanthine Drugs.. Int J Mol Sci, 18 (3): [PMID:28282918] |