PEPA - 98%, high purity , CAS No.141286-78-4

  • ≥98%
Item Number
P335717
Grouped product items
SKUSizeAvailabilityPrice Qty
P335717-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$141.90
P335717-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$616.90

an allosteric potentiator of AMPA desensitization

Basic Description

SynonymsPEPA | 141286-78-4 | 2,6-Difluoro-4-[2-(phenylsulfonylamino)ethylthio]phenoxyacetamide | 2-[4-[2-(benzenesulfonamido)ethylsulfanyl]-2,6-difluorophenoxy]acetamide | PEPA (DRUG) | 8S4PR7A8JS | 4-(2-(phenylsulfonylamino)ethylthio)-2,6-difluorophenoxyacetamide | 2-(2,6-Dif
Specifications & Purity≥98%
Storage TempRoom temperature
Shipped InNormal
Product Description

PEPA is an allosteric potentiator of AMPA desensitization. PEPA decreases the rate of onset of desensitization and potentiates steady-state equilibrium currents induced by Glu with splic variant and subunit selectivity. PEPA enhances post-ischemic memory impairment in rats post i.v. administration. AMPA is a transmembrane glutamate receptor composed of the subunits GluR-1,2,3,4. PEPA is an activator of GluR.

Product Properties

pKapKₐ: 10.44 (Predicted)

Associated Targets(Human)

CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GRIA3 Tclin Glutamate receptor ionotropic, AMPA 3 (127 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GRIA1 Tclin Glutamate receptor ionotropic, AMPA 1 (277 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NFKB1 Tclin Nuclear factor NF-kappa-B p105 subunit (1459 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SH-SY5Y (11521 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HEK293 (82097 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HIF1A Tchem Hypoxia-inducible factor 1 alpha (6027 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HSD17B10 Tchem Endoplasmic reticulum-associated amyloid beta-peptide-binding protein (20669 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PMP22 Tbio Peripheral myelin protein 22 (699 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ATXN2 Tbio Ataxin-2 (54410 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GRIA3 Tclin Glutamate receptor AMPA 2/3 (11 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Gria4 Glutamate receptor ionotropic, AMPA 4 (112 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
pfk 6-phospho-1-fructokinase (7870 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
nfo Endonuclease 4 (425 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NS1 Nonstructural protein 1 (33327 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Gria2 Glutamate receptor AMPA 1/2 (4 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Gria2 Glutamate receptor ionotropic, AMPA 2/3 (2 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Gria2 Glutamate receptor AMPA 2/4 (2 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name 2-[4-[2-(benzenesulfonamido)ethylsulfanyl]-2,6-difluorophenoxy]acetamide
INCHI InChI=1S/C16H16F2N2O4S2/c17-13-8-11(9-14(18)16(13)24-10-15(19)21)25-7-6-20-26(22,23)12-4-2-1-3-5-12/h1-5,8-9,20H,6-7,10H2,(H2,19,21)
InChi Key GTACSIONMHMRPD-UHFFFAOYSA-N
Canonical SMILES C1=CC=C(C=C1)S(=O)(=O)NCCSC2=CC(=C(C(=C2)F)OCC(=O)N)F
Isomeric SMILES C1=CC=C(C=C1)S(=O)(=O)NCCSC2=CC(=C(C(=C2)F)OCC(=O)N)F
WGK Germany 3
PubChem CID 6603828
Molecular Weight 402.44

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SolubilitySoluble in DMSO (100 mM), and ethanol (25 mM).
Refractive Indexn20D1.62 (Predicted)
Boil Point(°C)~617.6° C at 760 mmHg (Predicted)
Melt Point(°C)240.99° C (Predicted)

Safety and Hazards(GHS)

WGK Germany 3

Related Documents

Citations of This Product

1. Zhu Sining, Wan Haitao, Yan Zhibo, Xi Chen, Zhang Yuzhuo, Zhang Fan.  (2023)  Synthesis and characterization of epoxy resin-based ion-imprinted polymer for selective removal of copper ions.  KOREAN JOURNAL OF CHEMICAL ENGINEERING,  40  (9): (2356-2364).  [PMID:]
2. Hua Zhou, Liangdong Ye, Dongming Chen, Ziwei Li, Shanrong Li, Dacheng Li, Zhiyi Huang, Zhouqiao Wei, Shaorong Lu.  (2023)  A bio-based compatibilizer for improved interfacial compatibility in thermally conductive and electrically insulating graphite/high density poly(ethylene) composites.  JOURNAL OF VINYL & ADDITIVE TECHNOLOGY,  29  (6): (991-1001).  [PMID:]
3. Sining Zhu, Chen Xi, Yuzhuo Zhang, Fan Zhang.  (2022)  Preparation and Characterization of Cadmium(II)-Ion-Imprinted Composites Based on Epoxy Resin.  ACS Applied Polymer Materials,  (12): (9284–9293).  [PMID:]
4. Yufei Liu, Yikai Zhan, Min He, Chengjun Xiao, Shan Liu, Shuhao Qin, Jie Yu.  (2022)  Amino-functionalized carbon fiber/polyamide 6 composites with enhanced interfacial and mechanical properties.  Journal of Materials Research and Technology-JMR&T,  20  (3229).  [PMID:]
5. Xiaofei Yan, Jie Fang, Jianjun Gu, Chenkai Zhu, Dongming Qi.  (2022)  Flame Retardancy, Thermal and Mechanical Properties of Novel Intumescent Flame Retardant/MXene/Poly(Vinyl Alcohol) Nanocomposites.  Nanomaterials,  12  (3): (477).  [PMID:35159825]

References

1. Zhu Sining, Wan Haitao, Yan Zhibo, Xi Chen, Zhang Yuzhuo, Zhang Fan.  (2023)  Synthesis and characterization of epoxy resin-based ion-imprinted polymer for selective removal of copper ions.  KOREAN JOURNAL OF CHEMICAL ENGINEERING,  40  (9): (2356-2364).  [PMID:]
2. Hua Zhou, Liangdong Ye, Dongming Chen, Ziwei Li, Shanrong Li, Dacheng Li, Zhiyi Huang, Zhouqiao Wei, Shaorong Lu.  (2023)  A bio-based compatibilizer for improved interfacial compatibility in thermally conductive and electrically insulating graphite/high density poly(ethylene) composites.  JOURNAL OF VINYL & ADDITIVE TECHNOLOGY,  29  (6): (991-1001).  [PMID:]
3. Sining Zhu, Chen Xi, Yuzhuo Zhang, Fan Zhang.  (2022)  Preparation and Characterization of Cadmium(II)-Ion-Imprinted Composites Based on Epoxy Resin.  ACS Applied Polymer Materials,  (12): (9284–9293).  [PMID:]
4. Yufei Liu, Yikai Zhan, Min He, Chengjun Xiao, Shan Liu, Shuhao Qin, Jie Yu.  (2022)  Amino-functionalized carbon fiber/polyamide 6 composites with enhanced interfacial and mechanical properties.  Journal of Materials Research and Technology-JMR&T,  20  (3229).  [PMID:]
5. Xiaofei Yan, Jie Fang, Jianjun Gu, Chenkai Zhu, Dongming Qi.  (2022)  Flame Retardancy, Thermal and Mechanical Properties of Novel Intumescent Flame Retardant/MXene/Poly(Vinyl Alcohol) Nanocomposites.  Nanomaterials,  12  (3): (477).  [PMID:35159825]

Solution Calculators