Determine the necessary mass, volume, or concentration for preparing a solution.
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
Basic Description
| Product Name | Pepstatin A TFA, CAS No.26305-03-3（free） |
|---|---|
| Synonyms | 3-hydroxy-4-[2-[[3-hydroxy-6-methyl-4-[[3-methyl-2-[[3-methyl-2-(3-methylbutanoylamino)butanoyl]amino]butanoyl]amino]heptanoyl]amino]propanoylamino]-6-methylheptanoic acid TFA |
| Product Description | Product Description Pepstatin A is a specific inhibitor of L-aspartic Acid produced by actinomycetes. It can inhibit the activities of hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease. The IC50 values are 4.5 nM, 6.2 nM, 150 nM, 290 nM, respectively, 520nm and 260nm, and inhibit the activity of HIV protease. Product Application Can be used in conjunction with E64-d and Leupeptin A to inhibit the degradation of autophagic cargo inside autophagosomes. For this application, the working concentration is typically between 1-10 μM. |
| Specifications & Purity | ≥97% |
| Biochemical and Physiological Mechanisms | Pepstatin A is an inhibitor of acid proteases (aspartyl peptidases). It forms a 1:1 complex with proteases such as pepsin, renin, cathepsin D, bovine chymosin, and protease B (Aspergillus niger). The inhibitor is highly selective and does not inhibit thio |
| Sequence | IsoValeryl-Val-Val-Sta-Ala-Sta-OH |
Associated Targets(Human)
CTSL Tclin Cathepsin L1 (0 Activities)
CTSE Tchem Cathepsin E (0 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
PGA5 Tclin Pepsin A-5 (0 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
REN Tclin Renin (0 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
CTSD Tchem Cathepsin D (0 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
ADAM9 Tchem Disintegrin and metalloproteinase domain-containing protein 9 (0 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
Product Specifications
| Storage Temp | Store at -20°C |
|---|---|
| Shipped In | Ice chest + Ice pads |
| CAS | 26305-03-3（free） |
Certificates
Certificate of Analysis(COA)
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 B23271068 | Certificate of Analysis | Aug 23, 2022 | P359425 |
| B23271072 | Certificate of Analysis | Aug 23, 2022 | P359425 |
| B23271113 | Certificate of Analysis | Aug 23, 2022 | P359425 |
| B23271114 | Certificate of Analysis | Aug 23, 2022 | P359425 |
| B2327972 | Certificate of Analysis | Aug 23, 2022 | P359425 |
| B2327974 | Certificate of Analysis | Aug 23, 2022 | P359425 |
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