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peptide 18 , CAS No.P612698, Inhibitor of furin; paired basic amino acid cleaving enzyme;Inhibitor of proprotein convertase subtilisin/kexin type 2;Inhibitor of proprotein convertase subtilisin/kexin type 6;Inhibitor of proprotein convertase subtilisin/kexin type 7

Item Number
P612698
Grouped product items
SKUSizeAvailabilityPrice Qty
P612698-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,000.90
P612698-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,000.90
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View related series
furin，paired basic amino acid cleaving enzyme Inhibitor proprotein convertase subtilisin/kexin type 2 Inhibitor proprotein convertase subtilisin/kexin type 6 Inhibitor proprotein convertase subtilisin/kexin type 7 Inhibitor

Basic Description

SynonymsAc-LLLLRVK-Amba
Specifications & PurityMoligand™
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of furin; paired basic amino acid cleaving enzyme;Inhibitor of proprotein convertase subtilisin/kexin type 2;Inhibitor of proprotein convertase subtilisin/kexin type 6;Inhibitor of proprotein convertase subtilisin/kexin type 7

Associated Targets(Human)

FURIN Tchem Furin (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PCSK6 Tchem Proprotein convertase subtilisin/kexin type 6 (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PCSK7 Tchem Proprotein convertase subtilisin/kexin type 7 (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PCSK2 Tchem Neuroendocrine convertase 2 (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PCSK2 Tchem Prohormone convertase 2 (8 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PCSK7 Tchem Subtilisin/kexin type 7 (37 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
FURIN Tchem Furin (909 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PCSK6 Tchem Subtilisin/kexin type 6 (163 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DU-145 (51482 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PC-3 (62116 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
LNCaP (8286 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-methylbutanoyl]amino]-6-amino-N-[(4-carbamimidoylphenyl)methyl]hexanamide
INCHI InChI=1S/C51H90N14O8/c1-28(2)23-38(59-33(11)66)46(69)62-40(25-30(5)6)48(71)64-41(26-31(7)8)49(72)63-39(24-29(3)4)47(70)60-37(16-14-22-57-51(55)56)45(68)65-42(32(9)10)50(73)61-36(15-12-13-21-52)44(67)58-27-34-17-19-35(20-18-34)43(53)54/h17-20,28-32,36-42H,12-16,21-27,52H2,1-11H3,(H3,53,54)(H,58,67)(H,59,66)(H,60,70)(H,61,73)(H,62,69)(H,63,72)(H,64,71)(H,65,68)(H4,55,56,57)/t36-,37-,38-,39-,40-,41-,42-/m0/s1
InChi Key UFNWIBYSOUCSGW-FVMQRRFMSA-N
Canonical SMILES NCCCC[C@@H](C(=O)NCc1ccc(cc1)C(=N)N)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)C)CC(C)C)CC(C)C)CC(C)C)CC(C)C)CCCN=C(N)N
Isomeric SMILES CC(C)C[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC1=CC=C(C=C1)C(=N)N)NC(=O)C
PubChem CID 75593419

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Related Documents

 SDS

 Specification Sheet

References

1. Kwiatkowska A, Couture F, Levesque C, Ly K, Desjardins R, Beauchemin S, Prahl A, Lammek B, Neugebauer W, Dory YL et al..  (2014)  Design, synthesis, and structure-activity relationship studies of a potent PACE4 inhibitor..  J Med Chem,  57  (1): (98-109).  [PMID:24350995] [10.1021/op500134e]

Solution Calculators

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