Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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P421889-1ml | 1ml | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $241.90 |
Akt inhibitor; alkylphospholipid
Synonyms | Perifosine | 157716-52-4 | KRX-0401 | 1,1-Dimethylpiperidin-1-ium-4-yl octadecyl phosphate | Perifosine (KRX-0401) | (1,1-dimethylpiperidin-1-ium-4-yl) octadecyl phosphate | NSC 639966 | Perifosine [INN] | D 21266 | NSC-639966 | 1,1-dimethylpiperidinium-4-yl octadecyl phosph |
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Specifications & Purity | Moligand™, 10mM in Water |
Biochemical and Physiological Mechanisms | Perifosine (also KRX-0401) is an alkylphospholipid (octadecyl-(1,1-dimethyl-4-piperidylio) phosphate) which inhibits Akt activation. Perifosine has been studied for potential treatment of a wide variety of cancers. Targeting cellular membranes, Perifosine |
Storage Temp | Store at -80°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Product Description | Perifosine (KRX-0401) is a novel Akt inhibitor with IC50 of 4.7 μM, targets pleckstrin homology domain of Akt. Phase 3. |
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IUPAC Name | (1,1-dimethylpiperidin-1-ium-4-yl) octadecyl phosphate |
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INCHI | InChI=1S/C25H52NO4P/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-24-29-31(27,28)30-25-20-22-26(2,3)23-21-25/h25H,4-24H2,1-3H3 |
InChi Key | SZFPYBIJACMNJV-UHFFFAOYSA-N |
Canonical SMILES | CCCCCCCCCCCCCCCCCCOP(=O)([O-])OC1CC[N+](CC1)(C)C |
Isomeric SMILES | CCCCCCCCCCCCCCCCCCOP(=O)([O-])OC1CC[N+](CC1)(C)C |
WGK Germany | 3 |
PubChem CID | 148177 |
Molecular Weight | 461.66 |
Enter Lot Number to search for COA:
Sensitivity | Moisture Sensitive,Heat Sensitive |
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Melt Point(°C) | 232 °C |
Pictogram(s) | GHS08, GHS07 |
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Signal | Danger |
Hazard Statements | H319:Causes serious eye irritation H302:Harmful if swallowed H372:Causes damage to organs through prolonged or repeated exposure H360:May damage fertility or the unborn child H362:May cause harm to breast-fed children |
Precautionary Statements | P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P263:Avoid contact during pregnancy/while nursing. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P337+P317:If eye irritation persists: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |