Perzinfotel - 98%, high purity , Glutamate [NMDA] receptor antagonist, CAS No.144912-63-0, Glutamate [NMDA] receptor antagonist

  • ≥98%
Item Number
P648963
Grouped product items
SKUSizeAvailabilityPrice Qty
P648963-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$210.90
P648963-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$330.90
P648963-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,160.90

Basic Description

SynonymsPerzinfotel | 144912-63-0 | EAA-090 | FX5AUU7Z8T | WAY-126090 | (2-(8,9-Dioxo-2,6-diazabicyclo(5.2.0)non-1(7)-en-2-yl)ethyl)phosphonic acid | [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)ethyl]phosphonic acid | Phosphonic acid, (2-(8,9-dioxo-2,6-diazabicyclo(5
Specifications & Purity≥98%
Biochemical and Physiological MechanismsPerzinfotel (EAA-090) is a potent, selective, and competitive NMDA receptor antagonist with neuroprotective effects. Perzinfotel (EAA-090) shows high affinity ( IC 50 =30 nM) for the glutamate site.
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
Action TypeANTAGONIST
Mechanism of actionGlutamate [NMDA] receptor antagonist
Product Description

Perzinfotel (EAA-090) is a potent, selective, and competitive NMDA receptor antagonist with neuroprotective effects. Perzinfotel (EAA-090) shows high affinity ( IC 50 =30 nM) for the glutamate site

In Vitro

Perzinfotel blocks NMDA-induced currents with an IC 50 of 0.48 μM and glutamate-induced neurotoxicity with an IC 50 of 1.6 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:NMDA receptor

Product Properties

ALogP-1.6

Associated Targets(Human)

GRIN1 Tclin Glutamate [NMDA] receptor (933 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Glra1 Glycine receptor subunit alpha-1 (65 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Brain (1 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Blood (6 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasma (328 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Grin1 Glutamate NMDA receptor (6467 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name 2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)ethylphosphonic acid
INCHI InChI=1S/C9H13N2O5P/c12-8-6-7(9(8)13)11(3-1-2-10-6)4-5-17(14,15)16/h10H,1-5H2,(H2,14,15,16)
InChi Key BDABGOLMYNHHTR-UHFFFAOYSA-N
Canonical SMILES C1CNC2=C(C(=O)C2=O)N(C1)CCP(=O)(O)O
Isomeric SMILES C1CNC2=C(C(=O)C2=O)N(C1)CCP(=O)(O)O
WGK Germany 3
PubChem CID 6918236
Molecular Weight 260.18

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SolubilityDMSO : 20.83 mg/mL (80.06 mM; Need ultrasonic) H2O : 5.88 mg/mL (22.60 mM; ultrasonic and warming and heat to 60°C)

Safety and Hazards(GHS)

Pictogram(s) GHS06
Signal Danger
Hazard Statements

H300:Fatal if swallowed

Precautionary Statements

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P270:Do not eat, drink or smoke when using this product.

P330:Rinse mouth.

P301+P316:IF SWALLOWED: Get emergency medical help immediately.

WGK Germany 3
RIDADR UN28116.1/PGIII

Related Documents

Solution Calculators