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Pexidartinib - 98%, high purity , Stem cell growth factor receptor inhibitor, CAS No.1029044-16-3, Stem cell growth factor receptor inhibitor

  • Moligand™
  • ≥98%
Item Number
P171724
Grouped product items
SKUSizeAvailabilityPrice Qty
P171724-5mg
5mg
In stock
$48.90
P171724-10mg
10mg
In stock
$68.90
P171724-25mg
25mg
In stock
$108.90
P171724-50mg
50mg
In stock
$147.90
P171724-100mg
100mg
In stock
$187.90
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Bulk Order  SDS  DATASHEET

Potent and selective MCSF Receptor inhibitor

View related series
colony stimulating factor 1 receptor Inhibitor cyclin dependent kinase 19 Inhibitor fms related receptor tyrosine kinase 1 Inhibitor fms related receptor tyrosine kinase 3 Inhibitor kinase insert domain receptor Inhibitor KIT proto-oncogene，receptor tyrosine kinase Inhibitor LCK proto-oncogene，Src family tyrosine kinase Inhibitor neurotrophic receptor tyrosine kinase 3 Inhibitor

Basic Description

SynonymsPexidartinib|1029044-16-3|PLX3397|PLX-3397|Turalio|Pexidartinib (PLX3397)|CML-261|Pexidartinib [INN]|pexidartinibum|UNII-6783M2LV5X|Pexidartinib [USAN]|6783M2LV5X|5-((5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)-N-((6-(trifluoromethyl)pyridin-3-yl)methy
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsPotent\xa0MCSF Receptor (CSF1R)\xa0inhibitor (IC 50 = 13 nM). Also inhibits Kit (IC 50 = 16 nM) and Flt3 (IC 50 = 160 nM). Highly selective (IC 50 >1\xa0μM) against a panel of over 200 kinases.\xa0Inhibits MCSF Receptor-dependent proliferation (0.1 - 0.44
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionStem cell growth factor receptor inhibitor
NoteRefer to SDS for more information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Properties

ALogP4.5

Names and Identifiers

IUPAC Name 5-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-N-[[6-(trifluoromethyl)pyridin-3-yl]methyl]pyridin-2-amine
INCHI InChI=1S/C20H15ClF3N5/c21-15-6-16-14(10-28-19(16)29-11-15)5-12-2-4-18(26-7-12)27-9-13-1-3-17(25-8-13)20(22,23)24/h1-4,6-8,10-11H,5,9H2,(H,26,27)(H,28,29)
InChi Key JGWRKYUXBBNENE-UHFFFAOYSA-N
Canonical SMILES C1=CC(=NC=C1CC2=CNC3=C2C=C(C=N3)Cl)NCC4=CN=C(C=C4)C(F)(F)F
Isomeric SMILES C1=CC(=NC=C1CC2=CNC3=C2C=C(C=N3)Cl)NCC4=CN=C(C=C4)C(F)(F)F
PubChem CID 25151352
Molecular Weight 417.815

Certificates

Certificate of Analysis(COA)

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6 results found

Lot NumberCertificate TypeDateItem
B23221002Certificate of AnalysisOct 09, 2022 P171724
B23221017Certificate of AnalysisOct 09, 2022 P171724
B23221054Certificate of AnalysisOct 09, 2022 P171724
B23221056Certificate of AnalysisOct 09, 2022 P171724
B23221061Certificate of AnalysisOct 09, 2022 P171724
H2421029Certificate of AnalysisOct 09, 2022 P171724

Related Documents

 SDS

 Specification Sheet

Alternative Products

  1. Pexidartinib hydrochloride - 99%, used for , CAS No. 2040295-03-0, by Aladdin Scientific
    Pexidartinib hydrochloride, Stem cell growth factor receptor inhibitor

    Starting at $50.90

  2. Pexidartinib hydrochloride - 10mM in DMSO, used for , CAS No. 2040295-03-0(DMSO), by Aladdin Scientific
    Pexidartinib hydrochloride

    Starting at $55.90

References

1. Cupp JS, Miller MA, Montgomery KD, Nielsen TO, O'Connell JX, Huntsman D, van de Rijn M, Gilks CB, West RB.  (2007)  Translocation and expression of CSF1 in pigmented villonodular synovitis, tenosynovial giant cell tumor, rheumatoid arthritis and other reactive synovitides..  Am J Surg Pathol,  31  (6): (970-6).  [PMID:17527089]
2. Fiocco U, Sfriso P, Lunardi F, Pagnin E, Oliviero F, Scagliori E, Cozzi L, Vezzù M, Molena B, Scanu A et al..  (2010)  Molecular pathways involved in synovial cell inflammation and tumoral proliferation in diffuse pigmented villonodular synovitis..  Autoimmun Rev,  9  (11): (780-4).  [PMID:20620241]
3. Molena B, Sfriso P, Oliviero F, Pagnin E, Teramo A, Lunardi F, Stramare R, Scanu A, Nardacchione R, Rubaltelli L et al..  (2011)  Synovial colony-stimulating factor-1 mRNA expression in diffuse pigmented villonodular synovitis..  Clin Exp Rheumatol,  29  (3): (547-50).  [PMID:21640049]
4. Smith CC, Zhang C, Lin KC, Lasater EA, Zhang Y, Massi E, Damon LE, Pendleton M, Bashir A, Sebra R et al..  (2015)  Characterizing and Overriding the Structural Mechanism of the Quizartinib-Resistant FLT3 "Gatekeeper" F691L Mutation with PLX3397..  Cancer Discov,  5  (6): (668-79).  [PMID:25847190]
5. Tap WD, Wainberg ZA, Anthony SP, Ibrahim PN, Zhang C, Healey JH, Chmielowski B, Staddon AP, Cohn AL, Shapiro GI et al..  (2015)  Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor..  N Engl J Med,  373  (5): (428-37).  [PMID:26222558]

Solution Calculators

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