PF-00835231 - 10mM in DMSO, high purity , CAS No.870153-29-0

Item Number

P426549

• Synonyms: PF-00835231 | 870153-29-0 | B5R5IQ1D64 | PF00835231 | PF-835231 | (3S)-3-(((2S)-2-((4-Methoxy-1H-indole-2-carbonyl)amino)-4-methylpentanoyl)amino)-2-oxo-4-((3S)-2-oxopyrrolidin-3-yl)butanol | (3S)-3-((N-((4-Methoxy-1H-indol-2-yl)carbonyl)-L-leucyl)amino)-2-oxo-4-((3S
• Specifications & Purity: Moligand™, 10mM in DMSO
• Biochemical and Physiological Mechanisms: PF-00835231 is a 3CL^pro (M^pro) inhibitor that may targets SARS-CoV-2 protease 3CL^pro as a potential new treatment for COVID-19.
• Storage Temp: Store at -80°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™

Product Description

Information

PF-00835231 PF-00835231 is a 3CL pro (M pro ) inhibitor that may targets SARS-CoV-2 protease 3CL pro as a potential new treatment for COVID-19.

Targets

3CL^pro

In vitro

A time-of-drug-addition approach delineates the timing of early SARS-CoV-2 life cycle steps in A549^+ACE2 cells and validates PF-00835231\'s early time of action. In a model of the human polarized airway epithelium, PF-00835231 potently inhibits SARS-CoV-2 at low micromolar concentrations. PF-00835231 exhibits the potential as an effective SARS-CoV-2 antiviral.

Cell Research(from reference)

Cell lines：A549 cells, human airway epithelial cultures (HAEC) 

Concentrations：1 nM-10 μM 

Incubation Time：0-4 h