Potent EP2receptor antagonist (IC50= 16 nM for human EP2receptors). Displays over 2000-fold selectivity for EP2receptors over EP1, EP3, EP4, DP1amd CRTH2receptors; exhibits <30% binding at a diverse panel of GPCRs and ion channels at a concentration of 10
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
ANTAGONIST
Mechanism of action
Antagonist of EP 2 receptor
Product Description
Introduction:
PF-04418948 is an orally active, potent and selective prostaglandin EP2 receptor antagonist with an IC50 of 16 nM.
Associated Targets
CXCR4Tclin C-X-C chemokine receptor type 4 0 Activities
1.af Forselles KJ, Root J, Clarke T, Davey D, Aughton K, Dack K, Pullen N. (2011) In vitro and in vivo characterization of PF-04418948, a novel, potent and selective prostaglandin EP₂ receptor antagonist.. Br J Pharmacol, 164 (7):(1847-56). [PMID:21595651]
Solution Calculators
Molarity Calculator
Determine the necessary mass, volume, or concentration for preparing a solution.
Dilution Calculator
Determine the dilution needed to prepare a stock solution.
K2223459