PF-04859989 , CAS No.P612729

Item Number
P612729
Grouped product items
SKUSizeAvailabilityPrice Qty
P612729-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$400.90
P612729-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$950.90

Basic Description

Synonyms34783-48-7 | (3S)-3-amino-1-hydroxy-1,2,3,4-tetrahydroquinolin-2-one | PF-04859989 | (3S)-3-amino-1-hydroxy-3,4-dihydroquinolin-2-one | CHEMBL2047851 | (S)-3-Amino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one | PF 04859989 | GTPL9038 | SCHEMBL2132616 | HYTRYTZFJVVZAF-ZETCQYMHSA
Specifications & PurityMoligand™
GradeMoligand™

Associated Targets(Human)

AADAT Tchem Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial (6 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KYAT1 Tbio Kynurenine--oxoglutarate transaminase I (96 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AADAT Tchem Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial (207 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KYAT3 Tbio Kynurenine--oxoglutarate transaminase 3 (9 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Aadat Kynurenine/alpha-aminoadipate aminotransferase (41 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Canis familiaris (36305 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Brain (1 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasma (328 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cerebrospinal fluid (288 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Liver microsome (341 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name (3S)-3-amino-1-hydroxy-3,4-dihydroquinolin-2-one
INCHI InChI=1S/C9H10N2O2/c10-7-5-6-3-1-2-4-8(6)11(13)9(7)12/h1-4,7,13H,5,10H2/t7-/m0/s1
InChi Key HYTRYTZFJVVZAF-ZETCQYMHSA-N
Canonical SMILES O=C1[C@@H](N)Cc2c(N1O)cccc2
Isomeric SMILES C1[C@@H](C(=O)N(C2=CC=CC=C21)O)N
PubChem CID 22868923

Certificates

Certificate of Analysis(COA)

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Related Documents

References

1. Wang Y, Liu H, McKenzie G, Witting PK, Stasch JP, Hahn M, Changsirivathanathamrong D, Wu BJ, Ball HJ, Thomas SR et al..  (2010)  Kynurenine is an endothelium-derived relaxing factor produced during inflammation..  Nat Med,  16  (3): (279-85).  [PMID:20190767]
2. Nguyen NT, Kimura A, Nakahama T, Chinen I, Masuda K, Nohara K, Fujii-Kuriyama Y, Kishimoto T.  (2010)  Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanism..  Proc Natl Acad Sci USA,  107  (46): (19961-6).  [PMID:21041655]
3. Dounay AB, Anderson M, Bechle BM, Evrard E, Gan X, Kim JY, McAllister LA, Pandit J, Rong S, Salafia MA et al..  (2013)  PF-04859989 as a template for structure-based drug design: identification of new pyrazole series of irreversible KAT II inhibitors with improved lipophilic efficiency..  Bioorg Med Chem Lett,  23  (7): (1961-6).  [PMID:23466229]
4. Dounay AB, Anderson M, Bechle BM, Campbell BM, Claffey MM, Evdokimov A, Evrard E, Fonseca KR, Gan X, Ghosh S et al..  (2012)  Discovery of Brain-Penetrant, Irreversible Kynurenine Aminotransferase II Inhibitors for Schizophrenia..  ACS Med Chem Lett,  (3): (187-92).  [PMID:24900455]
5. Nematollahi A, Sun G, Jayawickrama GS, Church WB.  (2016)  Kynurenine Aminotransferase Isozyme Inhibitors: A Review..  Int J Mol Sci,  17  (6): (589-97).  [PMID:27314340]

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