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PF 04885614 - ≥98%(HPLC), high purity , CAS No.1480833-70-2, Inhibitor of K v11.1;Inhibitor of Na v1.6;Inhibitor of Na v1.8

Moligand™

≥98%(HPLC)

CAS#: 1480833-70-2
Formula: C₁₃H₁₄F₃N₃O
Molecular Weight: 285.26
PubChem CID: 65459349

Item Number

P288823

Grouped product items
SKU	Size	Availability	Price
P288823-5mg	5mg	In stock	$117.90
P288823-10mg	10mg	In stock	$187.90
P288823-25mg	25mg	In stock	$423.90
P288823-50mg	50mg	In stock	$662.90
P288823-100mg	100mg	In stock	$1,167.90
P288823-250mg	250mg	In stock	$2,628.90

Potent and selective NaV1.8 channel blocker; activein vivo

View related series

Kv11.1 Inhibitor Membrane Transporter/Ion Channel Nav1.6 Inhibitor Nav1.8 Inhibitor Sodium Channel

Basic Description

Specifications & Purity	Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms	Potent NaV1.8 inhibitor (IC50= 53 nM for human NaV1.8 channel). Exhibits selectivity for hNaV1.8 over hNaV1.6, hNaV1.7, hNaV1.1, hNaV1.2 and hNaV1.5 (IC50values are 4.2, 7.0, 11, 16 and 27μM respectively). PF-04885614 is an effective NaV1.8 inhibitor, ple
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of K v11.1;Inhibitor of Na v1.6;Inhibitor of Na v1.8

Associated Targets(Human)

SCN10A Tclin Sodium channel protein type 10 subunit alpha (1 Activities)

Discover Target: SCN10A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SCN9A Tclin Sodium channel protein type 9 subunit alpha (1 Activities)

Discover Target: SCN9A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SCN8A Tclin Sodium channel protein type 8 subunit alpha (1 Activities)

Discover Target: SCN8A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 (2 Activities)

Discover Target: KCNH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SCN1A Tclin Sodium channel protein type I alpha subunit (483 Activities)

Discover Target: SCN1A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KCNH2 Tclin HERG (29587 Activities)

Discover Target: KCNH2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SCN5A Tclin Sodium channel protein type V alpha subunit (3462 Activities)

Discover Target: SCN5A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Liver (3974 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Scn2a Sodium channel protein type II alpha subunit (191 Activities)

Discover Target: Scn2a

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Scn9a Sodium channel protein type IX alpha subunit (69 Activities)

Discover Target: Scn9a

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Scn8a Sodium channel protein type VIII alpha subunit (53 Activities)

Discover Target: Scn8a

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Scn10a Sodium channel protein type X alpha subunit (425 Activities)

Discover Target: Scn10a

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	2-[5-[4-(trifluoromethoxy)phenyl]-1H-imidazol-2-yl]propan-2-amine
INCHI	InChI=1S/C13H14F3N3O/c1-12(2,17)11-18-7-10(19-11)8-3-5-9(6-4-8)20-13(14,15)16/h3-7H,17H2,1-2H3,(H,18,19)
InChi Key	AGORGFNWYAUYSU-UHFFFAOYSA-N
Canonical SMILES	CC(C)(C1=NC=C(N1)C2=CC=C(C=C2)OC(F)(F)F)N
Isomeric SMILES	CC(C)(C1=NC=C(N1)C2=CC=C(C=C2)OC(F)(F)F)N
PubChem CID	65459349
Molecular Weight	285.26

PubChem CID

65459349

CAS Registry No.

1480833-70-2

ChEMBL Ligand

CHEMBL4084106

Certificates

Certificate of Analysis(COA)

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6 results found

Lot Number	Certificate Type	Date	Item
L2102055	Certificate of Analysis	Sep 19, 2024	P288823
L2102057	Certificate of Analysis	Sep 19, 2024	P288823
L2102058	Certificate of Analysis	Sep 19, 2024	P288823
L2102059	Certificate of Analysis	Sep 19, 2024	P288823
L2102060	Certificate of Analysis	Sep 19, 2024	P288823
L2102193	Certificate of Analysis	Sep 19, 2024	P288823

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PF 04885614 - ≥98%(HPLC), high purity , CAS No.1480833-70-2, Inhibitor of K v11.1;Inhibitor of Na v1.6;Inhibitor of Na v1.8

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Related Documents

Solution Calculators

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