PF-04929113 (SNX-5422) - ≥98%, high purity , Heat shock protein HSP90 inhibitor, CAS No.908115-27-5, Heat shock protein HSP90 inhibitor

  • ≥98%
Item Number
P126273
Grouped product items
SKUSizeAvailabilityPrice Qty
P126273-1mg
1mg
In stock
$65.90
P126273-5mg
5mg
In stock
$252.90
P126273-10mg
10mg
In stock
$438.90
P126273-25mg
25mg
In stock
$987.90
P126273-50mg
50mg
In stock
$1,003.90
P126273-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,805.90

Potent and selective Hsp90 inhibitor

Basic Description

Synonyms(1r,4r)-4-((2-carbamoyl-5-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenyl)amino)cyclohexyl glycinate | BBL027742 | ETHYL CYANOACETATE [HSDB] | EX-A2343 | PF-04929113 (SNX-5422) | Acetal resin | Glycine Trans-4-((2-(aminoc
Specifications & Purity≥98%
Biochemical and Physiological MechanismsPF-04929113 (SNX-5422) is a potent and selective Hsp90 inhibitor (Kd of 41 nM). PF-04929113 also inhibits Her-2 degradation (IC50 of 37 nM). PF-04929113 is a small-molecule Hsp90 inhibitor based on the 6,7-dihydro-indazol-4-one scaffold. PF-04929113 exhib
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
Action TypeINHIBITOR
Mechanism of actionHeat shock protein HSP90 inhibitor
NoteToxic, refer to SDS for further information Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

PF-04929113 (SNX-5422) is a potent and selective HSP90 inhibitor with Kd of 41 nM and induces Her-2 degradation with IC50 of 37 nM. Phase 1/2.

Product Properties

ALogP3.5

Associated Targets(Human)

HSP90AA1 Tchem Heat shock protein HSP 90-alpha (4115 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Escherichia coli (133304 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Bacillus subtilis (32866 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name [4-[2-carbamoyl-5-[6,6-dimethyl-4-oxo-3-(trifluoromethyl)-5,7-dihydroindazol-1-yl]anilino]cyclohexyl] 2-aminoacetate
INCHI InChI=1S/C25H30F3N5O4/c1-24(2)10-18-21(19(34)11-24)22(25(26,27)28)32-33(18)14-5-8-16(23(30)36)17(9-14)31-13-3-6-15(7-4-13)37-20(35)12-29/h5,8-9,13,15,31H,3-4,6-7,10-12,29H2,1-2H3,(H2,30,36)
InChi Key AVDSOVJPJZVBTC-UHFFFAOYSA-N
Canonical SMILES CC1(CC2=C(C(=O)C1)C(=NN2C3=CC(=C(C=C3)C(=O)N)NC4CCC(CC4)OC(=O)CN)C(F)(F)F)C
Isomeric SMILES CC1(CC2=C(C(=O)C1)C(=NN2C3=CC(=C(C=C3)C(=O)N)NC4CCC(CC4)OC(=O)CN)C(F)(F)F)C
PubChem CID 44195571
Molecular Weight 521.54

Certificates

Certificate of Analysis(COA)

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6 results found

Lot NumberCertificate TypeDateItem
E2230049Certificate of AnalysisMar 14, 2024 P126273
E2230050Certificate of AnalysisMar 14, 2024 P126273
E2230055Certificate of AnalysisMar 14, 2024 P126273
E2230056Certificate of AnalysisMar 14, 2024 P126273
E2230058Certificate of AnalysisMar 14, 2024 P126273
E2230059Certificate of AnalysisFeb 21, 2022 P126273

Chemical and Physical Properties

SolubilityDMSO 104 mg/mL Water <1 mg/mL Ethanol 5 mg/mL

Related Documents

Solution Calculators