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PF-04957325 , CAS No.1305115-80-3, Inhibitor of phosphodiesterase 8A

Moligand™

CAS#: 1305115-80-3
PubChem CID: 52938379

Item Number

P612731

Grouped product items
SKU	Size	Availability	Price	Qty
P612731-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
P612731-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,001.90

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phosphodiesterase 8A Inhibitor

Specifications & Purity

Moligand™

Grade

Moligand™

Action Type

INHIBITOR

Mechanism of action

Inhibitor of phosphodiesterase 8A

Associated Targets

PDE8A Tclin High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A 1 Activities

Discover Target: PDE8A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDE8B Tclin High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B 0 Activities

Discover Target: PDE8B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	3-[[(2R)-4-(1,3-thiazol-2-ylmethyl)morpholin-2-yl]methyl]-5-(trifluoromethyl)triazolo[4,5-d]pyrimidin-7-amine
INCHI	InChI=1S/C14H15F3N8OS/c15-14(16,17)13-20-11(18)10-12(21-13)25(23-22-10)6-8-5-24(2-3-26-8)7-9-19-1-4-27-9/h1,4,8H,2-3,5-7H2,(H2,18,20,21)/t8-/m1/s1
InChi Key	VNLPYEMGHGDRRZ-MRVPVSSYSA-N
Canonical SMILES	C1COC(CN1CC2=NC=CS2)CN3C4=NC(=NC(=C4N=N3)N)C(F)(F)F
Isomeric SMILES	C1CO[C@H](CN1CC2=NC=CS2)CN3C4=NC(=NC(=C4N=N3)N)C(F)(F)F
PubChem CID	52938379

CAS Registry No.

1305115-80-3

PubChem CID

52938379

References

1. Maurice DH, Ke H, Ahmad F, Wang Y, Chung J, Manganiello VC. (2014) Advances in targeting cyclic nucleotide phosphodiesterases.. Nat Rev Drug Discov, 13 (4): (290-314). [PMID:24687066]
2. Basole CP, Nguyen RK, Lamothe K, Vang A, Clark R, Baillie GS, Epstein PM, Brocke S. (2017) PDE8 controls CD4⁺ T cell motility through the PDE8A-Raf-1 kinase signaling complex.. Cell Signal, 40 (3): (62-72). [PMID:28851628]

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PF-04957325 , CAS No.1305115-80-3, Inhibitor of phosphodiesterase 8A

Basic Description

Associated Targets

PDE8A Tclin High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A 1 Activities

PDE8B Tclin High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B 0 Activities

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Related Documents

References

Solution Calculators

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Dilution Calculator

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