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Cyclic nucleotide turnover/signalling
PF-04957325 , CAS No.1305115-80-3, Inhibitor of phosphodiesterase 8A

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PF-04957325 , CAS No.1305115-80-3, Inhibitor of phosphodiesterase 8A

Moligand™

CAS#: 1305115-80-3
PubChem CID: 52938379

Item Number

P612731

Grouped product items
SKU	Size	Availability	Price	Qty
P612731-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
P612731-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,001.90

View related series

phosphodiesterase 8A Inhibitor

Basic Description

Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of phosphodiesterase 8A

Associated Targets(Human)

PDE8A Tclin High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (1 Activities)

Discover Target: PDE8A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Associated Targets(non-human)

Pde8a Phosphodiesterase 8A (1 Activities)

Discover Target: Pde8a

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	3-[[(2R)-4-(1,3-thiazol-2-ylmethyl)morpholin-2-yl]methyl]-5-(trifluoromethyl)triazolo[4,5-d]pyrimidin-7-amine
INCHI	InChI=1S/C14H15F3N8OS/c15-14(16,17)13-20-11(18)10-12(21-13)25(23-22-10)6-8-5-24(2-3-26-8)7-9-19-1-4-27-9/h1,4,8H,2-3,5-7H2,(H2,18,20,21)/t8-/m1/s1
InChi Key	VNLPYEMGHGDRRZ-MRVPVSSYSA-N
Canonical SMILES	C1COC(CN1CC2=NC=CS2)CN3C4=NC(=NC(=C4N=N3)N)C(F)(F)F
Isomeric SMILES	C1CO[C@H](CN1CC2=NC=CS2)CN3C4=NC(=NC(=C4N=N3)N)C(F)(F)F
PubChem CID	52938379

Database links

CAS Registry No.	1305115-80-3
PubChem CID	52938379

Certificates

Certificate of Analysis(COA)

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References

1. Maurice DH, Ke H, Ahmad F, Wang Y, Chung J, Manganiello VC. (2014) Advances in targeting cyclic nucleotide phosphodiesterases.. Nat Rev Drug Discov, 13 (4): (290-314). [PMID:24687066] [10.1021/op500134e]
2. Basole CP, Nguyen RK, Lamothe K, Vang A, Clark R, Baillie GS, Epstein PM, Brocke S. (2017) PDE8 controls CD4⁺ T cell motility through the PDE8A-Raf-1 kinase signaling complex.. Cell Signal, 40 (13): (62-72). [PMID:28851628] [10.1021/op500134e]

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