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PF-04971729 - 10mM in DMSO, high purity , CAS No.1210344-57-2
Basic Description Synonyms Ertugliflozin | 1210344-57-2 | PF-04971729 | Steglatro | PF04971729 | MK-8835 | PF 04971729 | (1S,2S,3S,4R,5S)-5-(4-chloro-3-(4-ethoxybenzyl)phenyl)-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol | UNII-6C282481IP | (1S,2S,3S,4R,5S)-5-[4-chloro-3-[(4-ethoxyphe Specifications & Purity Moligand™, 10mM in DMSO Biochemical and Physiological Mechanisms PF-04971729, a potent and selective inhibitor of the sodium-dependent glucose cotransporter 2, is currently in phase 2 trials for the treatment of diabetes mellitus. Inhibitory effects against the organic cation transporter 2-mediated upt
Storage Temp Store at -80°C Shipped In Ice chest + Ice pads Grade Moligand™ Product Description PF-04971729(Ertugliflozin) is a potent and selective inhibitor of the sodium-dependent glucose cotransporter 2(SGLT2).
Ertugliflozin (MK-8835, PF-04971729) is a potent and selective sodium-dependent glucose cotransporter 2 inhibitor with IC50 values of 0.877 nM for h-SGLT2 and 1000-fold higher for h-SGLT1.
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name (1S,2S,3S,4R,5S)-5-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol INCHI InChI=1S/C22H25ClO7/c1-2-28-16-6-3-13(4-7-16)9-14-10-15(5-8-17(14)23)22-20(27)18(25)19(26)21(11-24,30-22)12-29-22/h3-8,10,18-20,24-27H,2,9,11-12H2,1H3/t18-,19-,20+,21-,22-/m0/s1 InChi Key MCIACXAZCBVDEE-CUUWFGFTSA-N Canonical SMILES CCOC1=CC=C(C=C1)CC2=C(C=CC(=C2)C34C(C(C(C(O3)(CO4)CO)O)O)O)Cl Isomeric SMILES CCOC1=CC=C(C=C1)CC2=C(C=CC(=C2)[C@@]34[C@@H]([C@H]([C@@H]([C@@](O3)(CO4)CO)O)O)O)Cl PubChem CID 44814423 Molecular Weight 436.88
Chemical and Physical Properties Safety and Hazards(GHS) Pictogram(s) GHS05 Signal Danger Hazard Statements H314: Causes severe skin burns and eye damage
H318: Causes serious eye damage
Precautionary Statements P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P260: Do not breathe dust/fume/gas/mist/vapors/spray.
P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P363: Wash contaminated clothing before reuse.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P305+P354+P338: IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing.
P317: Get emergency medical help.
P302+P361+P354: IF ON SKIN: Take off Immediately all contaminated clothing. Immediately rinse with water for several minutes.
P316: Get emergency medical help immediately.
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