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PF 06273340 - ≥98%(HPLC), high purity , CAS No.1402438-74-7
Potent and selective pan-Trk inhibitor; peripherally restricted
Basic Description Synonyms I136775ABW | 3-(4-Chlorobenzoyl)propionic acid, 96% | BCP29619 | N-{5-[2-Amino-7-(1-Hydroxy-2-Methylpropan-2-Yl)-7h-Pyrrolo[2,3-D]pyrimidine-5-Carbonyl]pyridin-3-Yl}-2-(5-Chloropyridin-2-Yl)acetamide | CS-0087536 | N-(5-(2-amino-7-(1-hydroxy-2-methylpropa Specifications & Purity ≥98%(HPLC) Biochemical and Physiological Mechanisms Potent and selective pan-Trk inhibitor (IC50values are 1, 2 and 6 nM for Trk C, B and A, respectively). Selective for Trk over a panel of ion channels, receptors and other enzymes. Peripherally restricted. Exhibits efficacy in a rodent model of inflammato Storage Temp Store at -20°C Shipped In Ice chest + Ice pads
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name N-[5-[2-amino-7-(1-hydroxy-2-methylpropan-2-yl)pyrrolo[2,3-d]pyrimidine-5-carbonyl]pyridin-3-yl]-2-(5-chloropyridin-2-yl)acetamide INCHI InChI=1S/C23H22ClN7O3/c1-23(2,12-32)31-11-18(17-10-28-22(25)30-21(17)31)20(34)13-5-16(9-26-7-13)29-19(33)6-15-4-3-14(24)8-27-15/h3-5,7-11,32H,6,12H2,1-2H3,(H,29,33)(H2,25,28,30) InChi Key BPIWZDNVMQQBQX-UHFFFAOYSA-N Canonical SMILES CC(C)(CO)N1C=C(C2=CN=C(N=C21)N)C(=O)C3=CC(=CN=C3)NC(=O)CC4=NC=C(C=C4)Cl Isomeric SMILES CC(C)(CO)N1C=C(C2=CN=C(N=C21)N)C(=O)C3=CC(=CN=C3)NC(=O)CC4=NC=C(C=C4)Cl PubChem CID 66571548 Molecular Weight 479.93
Chemical and Physical Properties Solubility DMSO: 20 mg/mL, clear
Safety and Hazards(GHS) RIDADR NONHforallmodesoftransport
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