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PF 06281355 - ≥98%(HPLC), high purity , CAS No.1435467-38-1

≥98%(HPLC)

CAS#: 1435467-38-1
Formula: C₁₄H₁₅N₃O₄S
Molecular Weight: 321.35
PubChem CID: 71568997

Item Number

P287032

Grouped product items
SKU	Size	Availability	Price
P287032-5mg	5mg	In stock	$88.90
P287032-10mg	10mg	In stock	$147.90
P287032-25mg	25mg	In stock	$246.90
P287032-50mg	50mg	In stock	$444.90
P287032-100mg	100mg	In stock	$642.90

Selective myeloperoxidase (MPO) inhibitor

Basic Description

Synonyms	1435467-38-1 \| PF-1355 \| PF-06281355 \| CHEMBL3633459 \| 6-(2,5-Dimethoxyphenyl)-3,4-dihydro-4-oxo-2-thioxo-1(2H)-pyrimidineacetamide \| PF 06281355 \| 2-(6-(2,5-Dimethoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide \| SCHEMBL14936647 \| DTXSID601140746 \| BCP20
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	IC50 = 1.5 in human whole blood stimulated by selective myeloperoxidase (MPO) inhibitor (LPS) μ M）。 MPO is selective through a series of 50 receptors, enzymes, ion channels and transporters, including thyroid peroxidase. Inhibition of MPO activity in peri
Storage Temp	Room temperature
Shipped In	Normal

Associated Targets(Human)

MPO Tchem Myeloperoxidase (1 Activities)

Discover Target: MPO

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TPO Tclin Thyroid peroxidase (64 Activities)

Discover Target: TPO

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

OPRM1 Tclin Mu opioid receptor (19785 Activities)

Discover Target: OPRM1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MPO Tchem Myeloperoxidase (1002 Activities)

Discover Target: MPO

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Canis familiaris (36305 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rattus norvegicus (775804 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasma (328 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Liver microsome (341 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	2-[6-(2,5-dimethoxyphenyl)-4-oxo-2-sulfanylidenepyrimidin-1-yl]acetamide
INCHI	InChI=1S/C14H15N3O4S/c1-20-8-3-4-11(21-2)9(5-8)10-6-13(19)16-14(22)17(10)7-12(15)18/h3-6H,7H2,1-2H3,(H2,15,18)(H,16,19,22)
InChi Key	LJBUZOGABRDGBR-UHFFFAOYSA-N
Canonical SMILES	COC1=CC(=C(C=C1)OC)C2=CC(=O)NC(=S)N2CC(=O)N
Isomeric SMILES	COC1=CC(=C(C=C1)OC)C2=CC(=O)NC(=S)N2CC(=O)N
PubChem CID	71568997
Molecular Weight	321.35

Certificates

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5 results found

Lot Number	Certificate Type	Date	Item
C2304876	Certificate of Analysis	Oct 31, 2022	P287032
C2304878	Certificate of Analysis	Oct 31, 2022	P287032
C2304885	Certificate of Analysis	Oct 31, 2022	P287032
C2304886	Certificate of Analysis	Oct 31, 2022	P287032
C2304894	Certificate of Analysis	Oct 31, 2022	P287032

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