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PF 06281355 - ≥98%(HPLC), high purity , CAS No.1435467-38-1
Selective myeloperoxidase (MPO) inhibitor
Basic Description Synonyms A902780 | 2-(6-(2,5-Dimethoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide | EX-A4194 | 2-(6-(2,5-dimethoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2h)-yl) acetamide | PF-1355 | PF-06281355 (Free base) | SCHEMBL14936647 | PF 06281355 Specifications & Purity ≥98%(HPLC) Biochemical and Physiological Mechanisms IC50 = 1.5 in human whole blood stimulated by selective myeloperoxidase (MPO) inhibitor (LPS) μ M）。 MPO is selective through a series of 50 receptors, enzymes, ion channels and transporters, including thyroid peroxidase. Inhibition of MPO activity in peri Storage Temp Room temperature Shipped In Normal
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 2-[6-(2,5-dimethoxyphenyl)-4-oxo-2-sulfanylidenepyrimidin-1-yl]acetamide INCHI InChI=1S/C14H15N3O4S/c1-20-8-3-4-11(21-2)9(5-8)10-6-13(19)16-14(22)17(10)7-12(15)18/h3-6H,7H2,1-2H3,(H2,15,18)(H,16,19,22) InChi Key LJBUZOGABRDGBR-UHFFFAOYSA-N Canonical SMILES COC1=CC(=C(C=C1)OC)C2=CC(=O)NC(=S)N2CC(=O)N Isomeric SMILES COC1=CC(=C(C=C1)OC)C2=CC(=O)NC(=S)N2CC(=O)N PubChem CID 71568997 Molecular Weight 321.35
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 6.43, Max Conc. mM: 20 with gentle warming
Safety and Hazards(GHS) RIDADR NONHforallmodesoftransport
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C2304876