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PF-06282999 - 10mM in DMSO, high purity , CAS No.1435467-37-0
Basic Description Synonyms PF-06282999 | 1435467-37-0 | 2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide | YO3O4Q2NC8 | CHEMBL3633460 | PF06282999 | 2-[6-(5-chloro-2-methoxyphenyl)-4-oxo-2-sulfanylidenepyrimidin-1-yl]acetamide | 1(2H)-Pyrimidineacetamide, 6- Specifications & Purity Moligand™, 10mM in DMSO Biochemical and Physiological Mechanisms PF-06282999 is an orally bioavailable, irreversible inactivator of myeloperoxidase enzyme and is currently in clinical trials for the potential treatment of cardiovascular diseases. Storage Temp Store at -80°C Shipped In Ice chest + Ice pads Grade Moligand™ Product Description Information
PF-06282999 PF-06282999 is an orally bioavailable, irreversible inactivator of myeloperoxidase enzyme and is currently in clinical trials for the potential treatment of cardiovascular diseases.
Targets
MPO (LPS-stimulated human whole blood) 1.9 μM
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 2-[6-(5-chloro-2-methoxyphenyl)-4-oxo-2-sulfanylidenepyrimidin-1-yl]acetamide INCHI InChI=1S/C13H12ClN3O3S/c1-20-10-3-2-7(14)4-8(10)9-5-12(19)16-13(21)17(9)6-11(15)18/h2-5H,6H2,1H3,(H2,15,18)(H,16,19,21) InChi Key ICYNYWFGIDGBRD-UHFFFAOYSA-N Canonical SMILES COC1=C(C=C(C=C1)Cl)C2=CC(=O)NC(=S)N2CC(=O)N Isomeric SMILES COC1=C(C=C(C=C1)Cl)C2=CC(=O)NC(=S)N2CC(=O)N PubChem CID 71571306 Molecular Weight 325.77
Safety and Hazards(GHS) RIDADR NONHforallmodesoftransport
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