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Home Epigenetics PF 06409577 - 10mM in DMSO, high purity , CAS No.1467057-23-3
PF 06409577 - 10mM in DMSO, high purity , CAS No.1467057-23-3
Potent and selective allosteric activator of AMPK
Basic Description Synonyms 1467057-23-3 | PF-06409577 | 6-Chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylic acid | PF 06409577 | 6-chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic acid | A89WAM8FBH | PF06409577 | 6-Chloranyl-5-[4-(1-Oxidanylcyclobutyl)phenyl]-1~{h}-I Specifications & Purity 10mM in DMSO Biochemical and Physiological Mechanisms PF-06409577 preserves retinal pigment epithelium cells from UV radiation by activating AMPK (AMP-activated protein kinase) signaling. This orally bioavailable and possesses pharmacokinetic properties. PF-06409577 blocks de novo lipid and cholesterol synth Storage Temp Store at -80°C Shipped In Ice chest + Ice pads Product Description PF-06409577 is a 6-chloro-indole derivative obtained from 5-bromo-6-chloro-indole.
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 6-chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic acid INCHI InChI=1S/C19H16ClNO3/c20-16-9-17-14(15(10-21-17)18(22)23)8-13(16)11-2-4-12(5-3-11)19(24)6-1-7-19/h2-5,8-10,21,24H,1,6-7H2,(H,22,23) InChi Key FHQXLWCFSUSXBF-UHFFFAOYSA-N Canonical SMILES C1CC(C1)(C2=CC=C(C=C2)C3=C(C=C4C(=C3)C(=CN4)C(=O)O)Cl)O Isomeric SMILES C1CC(C1)(C2=CC=C(C=C2)C3=C(C=C4C(=C3)C(=CN4)C(=O)O)Cl)O PubChem CID 71748255 Molecular Weight 341.79
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P337+P313: IF eye irritation persists: Get medical advice/attention.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P332+P313: IF SKIN irritation occurs: Get medical advice/attention.
P304+P340+P312: IF INHALED: Remove person to fresh air and keep comfortable for breathing.Call a POISON CENTER or doctor. if you feel unwell.
RIDADR NONHforallmodesoftransport
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