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Activin and Inhibin
PF 06424439 - 10mM in DMSO, high purity , CAS No.1469284-79-4

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PF 06424439 - 10mM in DMSO, high purity , CAS No.1469284-79-4

10mM in DMSO

CAS#: 1469284-79-4
Formula: C₂₃H₃₀ClN₇O₄S
Molecular Weight: 536.05
PubChem CID: 89854212

Item Number

P421707

Grouped product items
SKU	Size	Availability	Price	Qty
P421707-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$241.90

Potent and selective DGAT2 inhibitor

Basic Description

Synonyms	[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinylmethanone methanesulfonate
Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	Potent and selective DGAT2 inhibitor (IC50= 14 nM). Exhibits no significant activity at MGAT1-3 or DGAT1. Reduces triglyderide synthesis in human hepatocytesin vitro. Reduces plasma triglyceride and cholesterol levels in a rat dyslipidemia model. Orally b
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads

Associated Targets(Human)

DGAT2 Tchem Diacylglycerol O-acyltransferase 2 (1 Activities)

Discover Target: DGAT2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)

Discover Target: CYP3A4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Canis familiaris (36305 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rattus norvegicus (775804 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	[(3R)-1-[2-[1-(4-chloropyrazol-1-yl)cyclopropyl]-1H-imidazo[4,5-b]pyridin-5-yl]piperidin-3-yl]-pyrrolidin-1-ylmethanone;methanesulfonic acid
INCHI	InChI=1S/C22H26ClN7O.CH4O3S/c23-16-12-24-30(14-16)22(7-8-22)21-25-17-5-6-18(26-19(17)27-21)29-11-3-4-15(13-29)20(31)28-9-1-2-10-28;1-5(2,3)4/h5-6,12,14-15H,1-4,7-11,13H2,(H,25,26,27);1H3,(H,2,3,4)/t15-;/m1./s1
InChi Key	ZSTFDNQQOJUJFL-XFULWGLBSA-N
Canonical SMILES	CS(=O)(=O)O.C1CCN(C1)C(=O)C2CCCN(C2)C3=NC4=C(C=C3)NC(=N4)C5(CC5)N6C=C(C=N6)Cl
Isomeric SMILES	CS(=O)(=O)O.C1CCN(C1)C(=O)[C@@H]2CCCN(C2)C3=NC4=C(C=C3)NC(=N4)C5(CC5)N6C=C(C=N6)Cl
WGK Germany	3
PubChem CID	89854212
Molecular Weight	536.05

Certificates

Certificate of Analysis(COA)

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Safety and Hazards(GHS)

WGK Germany	3
RIDADR	NONHforallmodesoftransport

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