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PF-06761281 , CAS No.1854061-19-0

CAS#: 1854061-19-0
Formula: C₁₆H₂₂O₅
Molecular Weight: 294.34
PubChem CID: 127029348

Item Number

P647906

Grouped product items
SKU	Size	Availability	Price
P647906-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$100.90
P647906-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$180.90
P647906-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$400.90
P647906-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$700.90

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Membrane Transporter/Ion Channel Sodium Channel

Basic Description

Biochemical and Physiological Mechanisms	PF-06761281 (Compound 4a) is a potent, orally active, partial selective sodium-coupled citrate transporter (NaCT or SLC13A5) inhibitor with IC 50 values of 0.51, 13.2 and 14.1 µM against HEK NaCT , HEK NaDC1 and HEK NaDC3 , respectively.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	PF-06761281 (Compound 4a) is a potent, orally active, partial selective sodium-coupled citrate transporter (NaCT or SLC13A5) inhibitor with IC 50 values of 0.51, 13.2 and 14.1 µM against HEK NaCT , HEK NaDC1 and HEK NaDC3 , respectively In Vitro PF-06761281 (Compound 4a) inhibits citrate uptake with IC 50 values of 0.12, 0.21 and 0.74 µM in rat, mouse and human Heps. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:IC 50 : 0.51 µM (HEK NaCT ), 13.2 µM (HEK NaDC1 ), 14.1 µM (HEK NaDC3 )

Associated Targets(Human)

SLC13A5 Tchem Solute carrier family 13 member 5 (2 Activities)

Discover Target: SLC13A5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC13A2 Tbio Solute carrier family 13 member 2 (3 Activities)

Discover Target: SLC13A2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLC13A3 Tbio Solute carrier family 13 member 3 (5 Activities)

Discover Target: SLC13A3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Mus musculus (284745 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rattus norvegicus (775804 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MDCK (10148 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	(2R)-2-[2-(4-tert-butylphenyl)ethyl]-2-hydroxybutanedioic acid
INCHI	InChI=1S/C16H22O5/c1-15(2,3)12-6-4-11(5-7-12)8-9-16(21,14(19)20)10-13(17)18/h4-7,21H,8-10H2,1-3H3,(H,17,18)(H,19,20)/t16-/m1/s1
InChi Key	QNFWRHKLBLSSPB-MRXNPFEDSA-N
Canonical SMILES	CC(C)(C)C1=CC=C(C=C1)CCC(CC(=O)O)(C(=O)O)O
Isomeric SMILES	CC(C)(C)C1=CC=C(C=C1)CC[C@@](CC(=O)O)(C(=O)O)O
PubChem CID	127029348
Molecular Weight	294.34

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PF-06761281 , CAS No.1854061-19-0

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Safety and Hazards(GHS)

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