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PF 3644022 - ≥98%(HPLC), high purity , CAS No.1276121-88-0, Inhibitor of MAPK activated protein kinase 2
Basic Description
| Specifications & Purity | Moligand™, ≥98%(HPLC) |
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| Biochemical and Physiological Mechanisms | Potent, ATP-competitive inhibitor of mitogen-activated protein kinase (MAPK)-activated protein kinase-2 (MK2) (IC50= 5.2 nM; Ki= 3 nM). Inhibits tumor necrosis factor α (TNFα) production in U937 monocytic cells and peripheral blood mononuclear cells (PBMC |
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| Storage Temp | Store at 2-8°C |
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| Shipped In | Wet ice |
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| Grade | Moligand™ |
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| Action Type | INHIBITOR |
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| Mechanism of action | Inhibitor of MAPK activated protein kinase 2 |
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Names and Identifiers
| IUPAC Name | (15R)-15-methyl-5-(6-methylpyridin-3-yl)-11-thia-6,14,17-triazatetracyclo[8.8.0.02,7.012,18]octadeca-1(10),2(7),3,5,8,12(18)-hexaen-13-one |
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| INCHI | InChI=1S/C21H18N4OS/c1-11-3-4-13(10-22-11)15-6-5-14-16(25-15)7-8-17-18(14)19-20(27-17)21(26)24-12(2)9-23-19/h3-8,10,12,23H,9H2,1-2H3,(H,24,26)/t12-/m1/s1 |
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| InChi Key | CMWRPDHVGMHLSZ-GFCCVEGCSA-N |
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| Canonical SMILES | CC1CNC2=C(C(=O)N1)SC3=C2C4=C(C=C3)N=C(C=C4)C5=CN=C(C=C5)C |
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| Isomeric SMILES | C[C@@H]1CNC2=C(C(=O)N1)SC3=C2C4=C(C=C3)N=C(C=C4)C5=CN=C(C=C5)C |
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| PubChem CID | 44631903 |
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| Molecular Weight | 374.46 |
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Chemical and Physical Properties
| Solubility | Solvent:DMSO, Max Conc. mg/mL: 14.98, Max Conc. mM: 40 |
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Safety and Hazards(GHS)
| Pictogram(s) | GHS07 |
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| Signal | Warning |
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| Hazard Statements | H319:Causes serious eye irritation H302:Harmful if swallowed |
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| Precautionary Statements | P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P337+P313:IF eye irritation persists: Get medical advice/attention. P301+P312+P330:IF SWALLOWED: Call a POISON CENTER/ doctor if you feel unwell. Rinse mouth. |
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References
| 1. Mourey RJ, Burnette BL, Brustkern SJ, Daniels JS, Hirsch JL, Hood WF, Meyers MJ, Mnich SJ, Pierce BS, Saabye MJ et al.. (2010) A benzothiophene inhibitor of mitogen-activated protein kinase-activated protein kinase 2 inhibits tumor necrosis factor alpha production and has oral anti-inflammatory efficacy in acute and chronic models of inflammation.. J Pharmacol Exp Ther, 333 (3): (797-807). [PMID:20237073] |
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C2214196