PF 3845 is a potent, selective, and irreversible FAAH (fatty acid amide hydrolase) inhibitor. Suggested to function by by carbamylating FAAH’s serine nucleophile.Selective, irreversible FAAH inhibitor (K i = 0.23 μM). Anti-inflammatory effects in vivo. Cr
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Storage Temp
Store at 2-8°C
Shipped In
Wet ice
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Inhibitor of Fatty acid amide hydrolase
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
PF-3845 is a potent, selective and irreversible FAAH inhibitor with Ki of 230 nM, showing negligible activity against FAAH2 A selective fatty acid amide hydrolase (FAAH) inhibitor.
1.Ahn K, Johnson DS, Mileni M, Beidler D, Long JZ, McKinney MK, Weerapana E, Sadagopan N, Liimatta M, Smith SE et al.. (2009) Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain.. Chem Biol, 16 (4):(411-20). [PMID:19389627][10.1021/op500134e]
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F1515084