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PF-431396 - ≥98%, high purity , CAS No.717906-29-1
Basic Description Synonyms 717906-29-1 | PF-431396 | PF 431396 | PF431396 | N-METHYL-N-[2-[[[2-[(2-OXO-2,3-DIHYDRO-1H-INDOL-5-YL)AMINO]-5-TRIFLUOROMETHYLPYRIMIDIN-4-YL]AMINO]METHYL]PHENYL]METHANESULFONAMIDE | N-Methyl-N-(2-(((2-((2-oxoindolin-5-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ami Specifications & Purity ≥98% Biochemical and Physiological Mechanisms Dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor (IC50values are 2 and 11 nM respectively). Promotes osteoblast recruitment and activity, and stimulates bone formation in ovariectomized rats. Storage Temp Store at 2-8°C Shipped In Wet ice Note 卖完停产，不再备货 Product Description PF-431396 is a dual PYK2/FAK inhibitor with IC50 of 11 nM and 2 nM, respectively.
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name N-methyl-N-[2-[[[2-[(2-oxo-1,3-dihydroindol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide INCHI InChI=1S/C22H21F3N6O3S/c1-31(35(2,33)34)18-6-4-3-5-13(18)11-26-20-16(22(23,24)25)12-27-21(30-20)28-15-7-8-17-14(9-15)10-19(32)29-17/h3-9,12H,10-11H2,1-2H3,(H,29,32)(H2,26,27,28,30) InChi Key POJZIZBONPAWIV-UHFFFAOYSA-N Canonical SMILES CN(C1=CC=CC=C1CNC2=NC(=NC=C2C(F)(F)F)NC3=CC4=C(C=C3)NC(=O)C4)S(=O)(=O)C Isomeric SMILES CN(C1=CC=CC=C1CNC2=NC(=NC=C2C(F)(F)F)NC3=CC4=C(C=C3)NC(=O)C4)S(=O)(=O)C PubChem CID 11598628 Molecular Weight 506.5
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 25.32, Max Conc. mM: 50
Safety and Hazards(GHS) Pictogram(s) GHS06 , GHS07 Signal Danger Hazard Statements H319: Causes serious eye irritation
H301: Toxic if swallowed
Precautionary Statements P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P301+P316: IF SWALLOWED: Get emergency medical help immediately.
P337+P317: If eye irritation persists: Get medical help.
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