The store will not work correctly when cookies are disabled.
JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.
PF-4708671 - 98%, high purity , CAS No.1255517-76-0, Inhibitor of ribosomal protein S6 kinase B1
Basic Description Synonyms PF-4708671|1255517-76-0|PF 4708671|PF4708671|2-((4-(5-Ethylpyrimidin-4-yl)piperazin-1-yl)methyl)-5-(trifluoromethyl)-1H-benzo[d]imidazole|PF-04708671|2-{[4-(5-Ethylpyrimidin-4-Yl)piperazin-1-Yl]methyl}-5-(Trifluoromethyl)-1h-Benzimidazole|CHEMBL2134202|2- Specifications & Purity Moligand™, ≥98% Biochemical and Physiological Mechanisms Cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) (Ki= 20 nM; IC50= 160 nM). Suppresses the S6K1-mediated phosphorylation of S6, Rictor and mTOR in response to IGF1; displays no effect on the activity of RSK and MSKin vivo. Exhibits no si Legal Information Sold for only research purposes Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type INHIBITOR Mechanism of action Inhibitor of ribosomal protein S6 kinase B1 Product Description PF-4708671
Names and Identifiers IUPAC Name 2-[[4-(5-ethylpyrimidin-4-yl)piperazin-1-yl]methyl]-6-(trifluoromethyl)-1H-benzimidazole INCHI InChI=1S/C19H21F3N6/c1-2-13-10-23-12-24-18(13)28-7-5-27(6-8-28)11-17-25-15-4-3-14(19(20,21)22)9-16(15)26-17/h3-4,9-10,12H,2,5-8,11H2,1H3,(H,25,26) InChi Key FBLPQCAQRNSVHB-UHFFFAOYSA-N Canonical SMILES CCC1=CN=CN=C1N2CCN(CC2)CC3=NC4=C(N3)C=C(C=C4)C(F)(F)F Isomeric SMILES CCC1=CN=CN=C1N2CCN(CC2)CC3=NC4=C(N3)C=C(C=C4)C(F)(F)F WGK Germany 3 PubChem CID 51371303 Molecular Weight 390.41
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 19.52, Max Conc. mM: 50; Solvent:ethanol, Max Conc. mg/mL: 19.52, Max Conc. mM: 50
Safety and Hazards(GHS) Pictogram(s) GHS06 Signal Danger Hazard Statements H301: Toxic if swallowed
Precautionary Statements P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P301+P316: IF SWALLOWED: Get emergency medical help immediately.
WGK Germany 3
References 1. Pearce LR, Alton GR, Richter DT, Kath JC, Lingardo L, Chapman J, Hwang C, Alessi DR. (2010) Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1).. Biochem J, 431 (2): (245-55). [PMID:20704563 ]
Solution Calculators Molarity Calculator Determine the necessary mass, volume, or concentration for preparing a solution.
Dilution Calculator Determine the dilution needed to prepare a stock solution.
Reconstitution Calculator
G2226413