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PF-4708671 - 98%, high purity , CAS No.1255517-76-0, Inhibitor of ribosomal protein S6 kinase B1
Basic Description Synonyms AKOS024457939 | BCP07961 | CS-1739 | MFCD18086922 | HY-15773 | CCG-222583 | Prestwick2_001094 | FBLPQCAQRNSVHB-UHFFFAOYSA-N | D0178 | J-015549 | 2-[[4-(5-Ethylpyrimidin-4-yl)piperazin-1-yl]methyl]-5-(trifluoromethyl)-1H-benzo[d]imidazole | 2-[[4-(5-ethylp Specifications & Purity Moligand™, ≥98% Biochemical and Physiological Mechanisms Cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) (Ki= 20 nM; IC50= 160 nM). Suppresses the S6K1-mediated phosphorylation of S6, Rictor and mTOR in response to IGF1; displays no effect on the activity of RSK and MSKin vivo. Exhibits no si Legal Information Sold for only research purposes Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type INHIBITOR Mechanism of action Inhibitor of ribosomal protein S6 kinase B1 Product Description PF-4708671
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 2-[[4-(5-ethylpyrimidin-4-yl)piperazin-1-yl]methyl]-6-(trifluoromethyl)-1H-benzimidazole INCHI InChI=1S/C19H21F3N6/c1-2-13-10-23-12-24-18(13)28-7-5-27(6-8-28)11-17-25-15-4-3-14(19(20,21)22)9-16(15)26-17/h3-4,9-10,12H,2,5-8,11H2,1H3,(H,25,26) InChi Key FBLPQCAQRNSVHB-UHFFFAOYSA-N Canonical SMILES CCC1=CN=CN=C1N2CCN(CC2)CC3=NC4=C(N3)C=C(C=C4)C(F)(F)F Isomeric SMILES CCC1=CN=CN=C1N2CCN(CC2)CC3=NC4=C(N3)C=C(C=C4)C(F)(F)F WGK Germany 3 PubChem CID 51371303 Molecular Weight 390.41
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 19.52, Max Conc. mM: 50; Solvent:ethanol, Max Conc. mg/mL: 19.52, Max Conc. mM: 50
Safety and Hazards(GHS) Pictogram(s) GHS06 Signal Danger Hazard Statements H301: Toxic if swallowed
Precautionary Statements P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P301+P316: IF SWALLOWED: Get emergency medical help immediately.
WGK Germany 3
References 1. Pearce LR, Alton GR, Richter DT, Kath JC, Lingardo L, Chapman J, Hwang C, Alessi DR. (2010) Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1).. Biochem J, 431 (2): (245-55). [PMID:20704563 ] [10.1021/op500134e ]
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