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PF-477736 - 98%, high purity , CAS No.952021-60-2, Inhibitor of checkpoint kinase 1;Inhibitor of checkpoint kinase 2

Specifications & Purity:  98%
Item Number
P120184
Grouped product items
SKUSizeAvailabilityPrice Qty
P120184-5mg
5mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$88.90
P120184-25mg
25mg
In stock
$400.90
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Selective Chk1 inhibitor

View related series
checkpoint kinase 1 Inhibitor checkpoint kinase 2 Inhibitor

Basic Description

SynonymsPF-477736|952021-60-2|PF 477736|PF477736|PF-00477736|PF0477736|PF 00477736|XO23PGZ0SM|(2R)-2-Amino-2-cyclohexyl-N-[2-(1-methyl-1H-pyrazol-4-yl)-6-oxo-5,6-dihydro-1H-[1,2]diazepino[4,5,6-cd]indol-8-yl]-acetamide|CHEMBL3990456|952021-60-2 (free base)|(2R)-2
Specifications & Purity98%
Storage TempStore at 2-8°C
Shipped InWet ice
Action TypeINHIBITOR
Mechanism of actionInhibitor of checkpoint kinase 1;Inhibitor of checkpoint kinase 2

Associated Targets

CHEK1 Tchem Serine/threonine-protein kinase Chk1 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CHEK2 Tchem Serine/threonine-protein kinase Chk2 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name (2R)-2-amino-2-cyclohexyl-N-[2-(1-methylpyrazol-4-yl)-9-oxo-3,10,11-triazatricyclo[6.4.1.04,13]trideca-1,4,6,8(13),11-pentaen-6-yl]acetamide
INCHI InChI=1S/C22H25N7O2/c1-29-11-13(9-25-29)20-16-10-24-28-21(30)15-7-14(8-17(27-20)18(15)16)26-22(31)19(23)12-5-3-2-4-6-12/h7-12,19,27H,2-6,23H2,1H3,(H,26,31)(H,28,30)/t19-/m1/s1
InChi Key NDEXUOWTGYUVGA-LJQANCHMSA-N
Canonical SMILES CN1C=C(C=N1)C2=C3C=NNC(=O)C4=C3C(=CC(=C4)NC(=O)C(C5CCCCC5)N)N2
Isomeric SMILES CN1C=C(C=N1)C2=C3C=NNC(=O)C4=C3C(=CC(=C4)NC(=O)[C@@H](C5CCCCC5)N)N2
WGK Germany 3
PubChem CID 135565545
Molecular Weight 419.48

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2 results found

Lot NumberCertificate TypeDateItem
K1827116Certificate of AnalysisSep 19, 2022 P120184
K1827115Certificate of AnalysisSep 19, 2022 P120184

Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: 31.46, Max Conc. mM: 75

Safety and Hazards(GHS)

WGK Germany 3

Related Documents

 SDS

 Specification Sheet

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References

1. Blasina A, Hallin J, Chen E, Arango ME, Kraynov E, Register J, Grant S, Ninkovic S, Chen P, Nichols T et al..  (2008)  Breaching the DNA damage checkpoint via PF-00477736, a novel small-molecule inhibitor of checkpoint kinase 1..  Mol Cancer Ther,  7  (8): (2394-404).  [PMID:18723486]

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